Outcome prediction of enteral levodopa/carbidopa infusion in advanced Parkinson's disease

Two studies comparing intraduodenal infusion of a levodopa/carbidopa gel with oral treatments in advanced PD patients demonstrated improvement in UPDRS scores and in frequent clinical ratings on a global treatment response scale. Further analysis of data from these studies was performed to find pred...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2006-12, Vol.12 (8), p.509-513
Main Authors: Westin, J., Nyholm, D., Groth, T., Dougherty, M.S., Yerramsetty, P.K., Palhagen, S.E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carbidopa - administration & dosage
continous dopaminergic stimulation
Continuous dopaminergic stimulation
Dopamine Agents - administration & dosage
Drug Administration Routes
Female
Humans
Improvement measure
infusion
levodopa
Levodopa - administration & dosage
Levodopa infusion
Linear Models
Male
Medical Informatics
MEDICIN
MEDICINE
Medicinsk informatik
Middle Aged
Neurologi
Neurology
Outcome prediction
Parkinson Disease - drug therapy
Parkinson's disease
Predictive factor
predictive factor Parkinson
predictive model
Predictive Value of Tests
Treatment Outcome
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Description
Summary:Two studies comparing intraduodenal infusion of a levodopa/carbidopa gel with oral treatments in advanced PD patients demonstrated improvement in UPDRS scores and in frequent clinical ratings on a global treatment response scale. Further analysis of data from these studies was performed to find predictive factors related to degree of improvement with infusion. Pearson's correlation coefficients between measures of improvement and baseline variables were calculated. Using data from one study, a prediction model was designed and was then evaluated using the other study's data. Correlations were found indicating that patients with more severe symptoms at baseline were most improved after infusion.
ISSN:1353-8020
1873-5126
1873-5126
DOI:10.1016/j.parkreldis.2006.02.006