Antibodies to kidney endothelial cells contribute to a "leaky" glomerular barrier in patients with chronic kidney diseases

Anti-endothelial cell antibodies (AECA) have been reported to cause endothelial dysfunction, but their clinical importance for tissue-specific endothelial cells is not clear. We hypothesized that AECA reactive with human kidney endothelial cells (HKEC) may cause renal endothelial dysfunction in pati...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2012-04, Vol.302 (7), p.F884-F894
Main Authors: Hernandez, Nidia Maritza, Casselbrant, Anna, Joshi, Meghnad, Johansson, Bengt R, Sumitran-Holgersson, Suchitra
Format: Article
Language:English
Subjects:
Actins - metabolism
Adherens Junctions - physiology
Adult
Antigens, CD - metabolism
Autoantibodies - physiology
Cadherins - metabolism
Calcium - metabolism
Case-Control Studies
Cells
Claudin-1
Clinical Medicine
Cytosol - metabolism
Female
Glomerular Filtration Barrier - metabolism
Humans
Hypertension
Immunoglobulin G - blood
Kidney diseases
Kidney Failure, Chronic - immunology
Kidney Failure, Chronic - metabolism
Klinisk medicin
Male
Membrane Proteins - metabolism
Middle Aged
Phosphorylation
Pilot Projects
Proteins
Tight Junctions - physiology
Tissues
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Summary:Anti-endothelial cell antibodies (AECA) have been reported to cause endothelial dysfunction, but their clinical importance for tissue-specific endothelial cells is not clear. We hypothesized that AECA reactive with human kidney endothelial cells (HKEC) may cause renal endothelial dysfunction in patients with chronic kidney diseases. We report that a higher fraction (56%) of end-stage renal disease (ESRD) patients than healthy controls (5%) have AECA reactive against kidney endothelial cells (P
ISSN:1931-857X
1522-1466
1522-1466
DOI:10.1152/ajprenal.00250.2011