Incorporation of 6-Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia-The Influence of Thiopurine Methyltransferase Genotypes

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Bibliographic Details
Published in:Journal of clinical pharmacology 2013-06, Vol.53 (6), p.670-674
Main Authors: Ebbesen, Maria S., Nersting, Jacob, Jacobsen, Jack H., Frandsen, Thomas L., Vettenranta, Kim, Abramsson, Jonas, Wesenberg, Finn, Schmiegelow, Kjeld
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Child
Clinical Medicine
DNA - metabolism
DNA-TG
Female
Genotype
Guanine Nucleotides - metabolism
Humans
Klinisk medicin
maintenance therapy
Male
Mercaptopurine - administration & dosage
Methotrexate - administration & dosage
Methyltransferases - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Thionucleotides - metabolism
thiopurine methyltransferase
thiopurines
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ISSN:0091-2700
1552-4604
DOI:10.1002/jcph.81