Ghrelin in cardiovascular disease and atherogenesis

Although initially associated with regulation of appetite, the cardiovascular system has also been recognized as a potentially important target for ghrelin. Moreover, a limited number of clinical studies suggest a role for ghrelin in the treatment of congestive heart failure. So far reported cardiov...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2011-06, Vol.340 (1), p.59-64
Main Authors: Isgaard, Jörgen, Granata, Riccarda
Format: Article
Language:English
Subjects:
Animals
appetite
atherogenesis
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Atherosclerosis - physiopathology
Biochemistry, Molecular Biology
Biological
Biomedical materials
cardioprotective effect
Cardiotonic Agents
Cardiotonic Agents - metabolism
Cardiovascular
Cardiovascular system
Clinical Medicine
clinical trials
Control
Ghrelin
Ghrelin - metabolism
Growth hormones
Heart failure
Humans
In vivo testing
In vivo tests
Klinisk medicin
Life Sciences
metabolism
Models, Biological
Myocardial Contraction
Myocardial Contraction - physiology
pathology
physiology
physiopathology
Recognition
somatotropin
Surgical implants
Vasodilation
Vasodilation - physiology
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Summary:Although initially associated with regulation of appetite, the cardiovascular system has also been recognized as a potentially important target for ghrelin. Moreover, a limited number of clinical studies suggest a role for ghrelin in the treatment of congestive heart failure. So far reported cardiovascular effects of growth hormone secretagogues and/or ghrelin include lowering of peripheral resistance, either direct at the vascular level and/or by modulating sympathetic nervous activity. Other observed effects indicate possible improvement of contractility and cardioprotective effects both in vivo and in vitro.Taken together, these results offer an interesting perspective on the future where further studies aiming at evaluating a role of GHS and ghrelin in the treatment of cardiovascular disease are warranted.
ISSN:0303-7207
1872-8057
1872-8057
0303-7207
DOI:10.1016/j.mce.2011.03.006