Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice

A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on dev...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Ulleryd, Marcus A., Bernberg, Evelina, Yang, Li Jin, Bergström, Göran M. L., Johansson, Maria E.
Format: Article
Language:English
Subjects:
ACCELERATES ATHEROSCLEROSIS
Adrenergic beta-1 Receptor Antagonists - pharmacology
Age
ANGIOTENSIN-II
Animals
Aorta, Thoracic - metabolism
Aorta, Thoracic - pathology
APOE-DEFICIENT
Apolipoproteins E - deficiency
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - drug therapy
Atherosclerosis - genetics
Atherosclerosis - pathology
BETA-BLOCKADE
Biotechnology & Applied Microbiology
BLOOD-PRESSURE
Chemokine CXCL1 - blood
Chemokines
Cholesterol
Cholesterol - blood
Cholesterol - genetics
CYNOMOLGUS
Drug dosages
Heart
Heart attacks
Heart rate
Hospitals
Humans
INTIMA-MEDIA THICKNESS
LOWERING ASYMPTOMATIC PLAQUE
Male
Medical Biotechnology
Medical research
Medicine
Medicinsk bioteknologi
Metoprolol - pharmacology
MICE
Mice, Knockout
MONKEYS
Plaque, Atherosclerotic - blood
Plaque, Atherosclerotic - drug therapy
Plaque, Atherosclerotic - genetics
Plaque, Atherosclerotic - pathology
Plasma
PSYCHOSOCIAL STRESS
Research & Experimental
Rodents
Studies
TNF-ALPHA
Tumor Necrosis Factor-alpha - blood
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Summary:A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/− mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/− mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/548783