Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice

A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on dev...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Ulleryd, Marcus A., Bernberg, Evelina, Yang, Li Jin, Bergström, Göran M. L., Johansson, Maria E.
Format: Article
Language:English
Subjects:
ACCELERATES ATHEROSCLEROSIS
Adrenergic beta-1 Receptor Antagonists - pharmacology
Age
ANGIOTENSIN-II
Animals
Aorta, Thoracic - metabolism
Aorta, Thoracic - pathology
APOE-DEFICIENT
Apolipoproteins E - deficiency
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - drug therapy
Atherosclerosis - genetics
Atherosclerosis - pathology
BETA-BLOCKADE
Biotechnology & Applied Microbiology
BLOOD-PRESSURE
Chemokine CXCL1 - blood
Chemokines
Cholesterol
Cholesterol - blood
Cholesterol - genetics
CYNOMOLGUS
Drug dosages
Heart
Heart attacks
Heart rate
Hospitals
Humans
INTIMA-MEDIA THICKNESS
LOWERING ASYMPTOMATIC PLAQUE
Male
Medical Biotechnology
Medical research
Medicine
Medicinsk bioteknologi
Metoprolol - pharmacology
MICE
Mice, Knockout
MONKEYS
Plaque, Atherosclerotic - blood
Plaque, Atherosclerotic - drug therapy
Plaque, Atherosclerotic - genetics
Plaque, Atherosclerotic - pathology
Plasma
PSYCHOSOCIAL STRESS
Research & Experimental
Rodents
Studies
TNF-ALPHA
Tumor Necrosis Factor-alpha - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3
cites cdi_FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3
container_end_page 7
container_issue 2014
container_start_page 1
container_title BioMed research international
container_volume 2014
creator Ulleryd, Marcus A.
Bernberg, Evelina
Yang, Li Jin
Bergström, Göran M. L.
Johansson, Maria E.
description A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/− mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/− mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P
doi_str_mv 10.1155/2014/548783
format article
fullrecord <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_gup_ub_gu_se_203054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1552373486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3</originalsourceid><addsrcrecordid>eNqFkl1rFDEUhoMottReea0MeCPKuPme5EZYlloLLYrU65DJJLupM5NpMmPZf-C1P9Ff0mynLtabBvJBzpOXk3NeAF4i-AEhxhYYIrpgVFSCPAGHmCBackTR0_2ZkANwnNIVzEMgDiV_Dg4wQ5AhLA_B5YUdwxBDG9rim20mY1PxNQbfu1Z3nR5D3Bar7Rh--D5HdN8Uy3FjY0im3a0-Fb4vlkM4-fPr9yLP4sIb-wI8c7pN9vh-PwLfP51crj6X519Oz1bL89IwUo2lFpILqWFT0Vo7Xhsia0odrhsoSNU0UkpuuBSUV5pxi5CsiHM10ZVlDXKGHIFy1k03dphqNUTf6bhVQXu1ngaVr9aTSlZhSCCjmf848xnubGNsP0bdPnj2MNL7jVqHn4oiKDGussDbe4EYriebRtX5ZGzb6t6GKSnEEeIEE84eRxnDpCJU8Iy--Q-9ClPsc-XuKMEIFrvk38-UyXVP0bp93giqnRfUzgtq9kKmX__71T37t_MZeDcDG983-sY_ovZqhm1GrNN7mArIclduAZ4qxxU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552853284</pqid></control><display><type>article</type><title>Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice</title><source>Open Access: Wiley-Blackwell Open Access Journals</source><source>Publicly Available Content Database</source><creator>Ulleryd, Marcus A. ; Bernberg, Evelina ; Yang, Li Jin ; Bergström, Göran M. L. ; Johansson, Maria E.</creator><contributor>Toh, Ban-Hock</contributor><creatorcontrib>Ulleryd, Marcus A. ; Bernberg, Evelina ; Yang, Li Jin ; Bergström, Göran M. L. ; Johansson, Maria E. ; Toh, Ban-Hock</creatorcontrib><description>A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/− mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/− mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P&lt;0.05 versus Control). Further, metoprolol reduced serum TNFα and the chemokine CXCL1 (P&lt;0.01 versus Control for both) as well as decreasing the macrophage content in the plaques (P&lt;0.01 versus Control). Total cholesterol levels were not affected. In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE−/− mice. Metoprolol also decreased serum levels of proinflammatory cytokines TNFα and CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/548783</identifier><identifier>PMID: 25105129</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>ACCELERATES ATHEROSCLEROSIS ; Adrenergic beta-1 Receptor Antagonists - pharmacology ; Age ; ANGIOTENSIN-II ; Animals ; Aorta, Thoracic - metabolism ; Aorta, Thoracic - pathology ; APOE-DEFICIENT ; Apolipoproteins E - deficiency ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - drug therapy ; Atherosclerosis - genetics ; Atherosclerosis - pathology ; BETA-BLOCKADE ; Biotechnology &amp; Applied Microbiology ; BLOOD-PRESSURE ; Chemokine CXCL1 - blood ; Chemokines ; Cholesterol ; Cholesterol - blood ; Cholesterol - genetics ; CYNOMOLGUS ; Drug dosages ; Heart ; Heart attacks ; Heart rate ; Hospitals ; Humans ; INTIMA-MEDIA THICKNESS ; LOWERING ASYMPTOMATIC PLAQUE ; Male ; Medical Biotechnology ; Medical research ; Medicine ; Medicinsk bioteknologi ; Metoprolol - pharmacology ; MICE ; Mice, Knockout ; MONKEYS ; Plaque, Atherosclerotic - blood ; Plaque, Atherosclerotic - drug therapy ; Plaque, Atherosclerotic - genetics ; Plaque, Atherosclerotic - pathology ; Plasma ; PSYCHOSOCIAL STRESS ; Research &amp; Experimental ; Rodents ; Studies ; TNF-ALPHA ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Marcus A. Ulleryd et al.</rights><rights>Copyright © 2014 Marcus A. Ulleryd et al. Marcus A. Ulleryd et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Marcus A. Ulleryd et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3</citedby><cites>FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1552853284/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1552853284?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25105129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/203054$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Toh, Ban-Hock</contributor><creatorcontrib>Ulleryd, Marcus A.</creatorcontrib><creatorcontrib>Bernberg, Evelina</creatorcontrib><creatorcontrib>Yang, Li Jin</creatorcontrib><creatorcontrib>Bergström, Göran M. L.</creatorcontrib><creatorcontrib>Johansson, Maria E.</creatorcontrib><title>Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/− mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/− mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P&lt;0.05 versus Control). Further, metoprolol reduced serum TNFα and the chemokine CXCL1 (P&lt;0.01 versus Control for both) as well as decreasing the macrophage content in the plaques (P&lt;0.01 versus Control). Total cholesterol levels were not affected. In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE−/− mice. Metoprolol also decreased serum levels of proinflammatory cytokines TNFα and CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect.</description><subject>ACCELERATES ATHEROSCLEROSIS</subject><subject>Adrenergic beta-1 Receptor Antagonists - pharmacology</subject><subject>Age</subject><subject>ANGIOTENSIN-II</subject><subject>Animals</subject><subject>Aorta, Thoracic - metabolism</subject><subject>Aorta, Thoracic - pathology</subject><subject>APOE-DEFICIENT</subject><subject>Apolipoproteins E - deficiency</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - drug therapy</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - pathology</subject><subject>BETA-BLOCKADE</subject><subject>Biotechnology &amp; Applied Microbiology</subject><subject>BLOOD-PRESSURE</subject><subject>Chemokine CXCL1 - blood</subject><subject>Chemokines</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - genetics</subject><subject>CYNOMOLGUS</subject><subject>Drug dosages</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart rate</subject><subject>Hospitals</subject><subject>Humans</subject><subject>INTIMA-MEDIA THICKNESS</subject><subject>LOWERING ASYMPTOMATIC PLAQUE</subject><subject>Male</subject><subject>Medical Biotechnology</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicinsk bioteknologi</subject><subject>Metoprolol - pharmacology</subject><subject>MICE</subject><subject>Mice, Knockout</subject><subject>MONKEYS</subject><subject>Plaque, Atherosclerotic - blood</subject><subject>Plaque, Atherosclerotic - drug therapy</subject><subject>Plaque, Atherosclerotic - genetics</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Plasma</subject><subject>PSYCHOSOCIAL STRESS</subject><subject>Research &amp; Experimental</subject><subject>Rodents</subject><subject>Studies</subject><subject>TNF-ALPHA</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFkl1rFDEUhoMottReea0MeCPKuPme5EZYlloLLYrU65DJJLupM5NpMmPZf-C1P9Ff0mynLtabBvJBzpOXk3NeAF4i-AEhxhYYIrpgVFSCPAGHmCBackTR0_2ZkANwnNIVzEMgDiV_Dg4wQ5AhLA_B5YUdwxBDG9rim20mY1PxNQbfu1Z3nR5D3Bar7Rh--D5HdN8Uy3FjY0im3a0-Fb4vlkM4-fPr9yLP4sIb-wI8c7pN9vh-PwLfP51crj6X519Oz1bL89IwUo2lFpILqWFT0Vo7Xhsia0odrhsoSNU0UkpuuBSUV5pxi5CsiHM10ZVlDXKGHIFy1k03dphqNUTf6bhVQXu1ngaVr9aTSlZhSCCjmf848xnubGNsP0bdPnj2MNL7jVqHn4oiKDGussDbe4EYriebRtX5ZGzb6t6GKSnEEeIEE84eRxnDpCJU8Iy--Q-9ClPsc-XuKMEIFrvk38-UyXVP0bp93giqnRfUzgtq9kKmX__71T37t_MZeDcDG983-sY_ovZqhm1GrNN7mArIclduAZ4qxxU</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Ulleryd, Marcus A.</creator><creator>Bernberg, Evelina</creator><creator>Yang, Li Jin</creator><creator>Bergström, Göran M. L.</creator><creator>Johansson, Maria E.</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope></search><sort><creationdate>20140101</creationdate><title>Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice</title><author>Ulleryd, Marcus A. ; Bernberg, Evelina ; Yang, Li Jin ; Bergström, Göran M. L. ; Johansson, Maria E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>ACCELERATES ATHEROSCLEROSIS</topic><topic>Adrenergic beta-1 Receptor Antagonists - pharmacology</topic><topic>Age</topic><topic>ANGIOTENSIN-II</topic><topic>Animals</topic><topic>Aorta, Thoracic - metabolism</topic><topic>Aorta, Thoracic - pathology</topic><topic>APOE-DEFICIENT</topic><topic>Apolipoproteins E - deficiency</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - drug therapy</topic><topic>Atherosclerosis - genetics</topic><topic>Atherosclerosis - pathology</topic><topic>BETA-BLOCKADE</topic><topic>Biotechnology &amp; Applied Microbiology</topic><topic>BLOOD-PRESSURE</topic><topic>Chemokine CXCL1 - blood</topic><topic>Chemokines</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - genetics</topic><topic>CYNOMOLGUS</topic><topic>Drug dosages</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart rate</topic><topic>Hospitals</topic><topic>Humans</topic><topic>INTIMA-MEDIA THICKNESS</topic><topic>LOWERING ASYMPTOMATIC PLAQUE</topic><topic>Male</topic><topic>Medical Biotechnology</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicinsk bioteknologi</topic><topic>Metoprolol - pharmacology</topic><topic>MICE</topic><topic>Mice, Knockout</topic><topic>MONKEYS</topic><topic>Plaque, Atherosclerotic - blood</topic><topic>Plaque, Atherosclerotic - drug therapy</topic><topic>Plaque, Atherosclerotic - genetics</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Plasma</topic><topic>PSYCHOSOCIAL STRESS</topic><topic>Research &amp; Experimental</topic><topic>Rodents</topic><topic>Studies</topic><topic>TNF-ALPHA</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulleryd, Marcus A.</creatorcontrib><creatorcontrib>Bernberg, Evelina</creatorcontrib><creatorcontrib>Yang, Li Jin</creatorcontrib><creatorcontrib>Bergström, Göran M. L.</creatorcontrib><creatorcontrib>Johansson, Maria E.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulleryd, Marcus A.</au><au>Bernberg, Evelina</au><au>Yang, Li Jin</au><au>Bergström, Göran M. L.</au><au>Johansson, Maria E.</au><au>Toh, Ban-Hock</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/− mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/− mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P&lt;0.05 versus Control). Further, metoprolol reduced serum TNFα and the chemokine CXCL1 (P&lt;0.01 versus Control for both) as well as decreasing the macrophage content in the plaques (P&lt;0.01 versus Control). Total cholesterol levels were not affected. In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE−/− mice. Metoprolol also decreased serum levels of proinflammatory cytokines TNFα and CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25105129</pmid><doi>10.1155/2014/548783</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6133
ispartof BioMed research international, 2014-01, Vol.2014 (2014), p.1-7
issn 2314-6133
2314-6141
language eng
recordid cdi_swepub_primary_oai_gup_ub_gu_se_203054
source Open Access: Wiley-Blackwell Open Access Journals; Publicly Available Content Database
subjects ACCELERATES ATHEROSCLEROSIS
Adrenergic beta-1 Receptor Antagonists - pharmacology
Age
ANGIOTENSIN-II
Animals
Aorta, Thoracic - metabolism
Aorta, Thoracic - pathology
APOE-DEFICIENT
Apolipoproteins E - deficiency
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - drug therapy
Atherosclerosis - genetics
Atherosclerosis - pathology
BETA-BLOCKADE
Biotechnology & Applied Microbiology
BLOOD-PRESSURE
Chemokine CXCL1 - blood
Chemokines
Cholesterol
Cholesterol - blood
Cholesterol - genetics
CYNOMOLGUS
Drug dosages
Heart
Heart attacks
Heart rate
Hospitals
Humans
INTIMA-MEDIA THICKNESS
LOWERING ASYMPTOMATIC PLAQUE
Male
Medical Biotechnology
Medical research
Medicine
Medicinsk bioteknologi
Metoprolol - pharmacology
MICE
Mice, Knockout
MONKEYS
Plaque, Atherosclerotic - blood
Plaque, Atherosclerotic - drug therapy
Plaque, Atherosclerotic - genetics
Plaque, Atherosclerotic - pathology
Plasma
PSYCHOSOCIAL STRESS
Research & Experimental
Rodents
Studies
TNF-ALPHA
Tumor Necrosis Factor-alpha - blood
title Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/− Mice
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T09%3A44%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metoprolol%20Reduces%20Proinflammatory%20Cytokines%20and%20Atherosclerosis%20in%20ApoE%E2%88%92/%E2%88%92%20Mice&rft.jtitle=BioMed%20research%20international&rft.au=Ulleryd,%20Marcus%20A.&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/548783&rft_dat=%3Cproquest_swepu%3E1552373486%3C/proquest_swepu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c537t-a89689a0d74baf6bc39b44f2bd0837dd9996c698467a56e11973ffb3a7e5d1fc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1552853284&rft_id=info:pmid/25105129&rfr_iscdi=true