Signalling Molecules in the Urothelium

The urothelium was long considered to be a silent barrier protecting the body from the toxic effects of urine. However, today a number of dynamic abilities of the urothelium are well recognized, including its ability to act as a sensor of the intravesical environment. During recent years several pat...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-14
Main Authors: Romih, Rok, Zupančič, Daša, Tobin, Gunnar, Winder, Michael
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Adenosine - metabolism
Adenosine Triphosphate - metabolism
Animals
Bladder
Colleges & universities
Enzymes
Epidermal growth factor
Excretory system
Farmakologi och toxikologi
Health aspects
Humans
Ligands (Biochemistry)
Models, Biological
Muscle, Smooth - physiopathology
Nitric oxide
Nitric Oxide - metabolism
Pharmacology and Toxicology
Review
Rodents
Signal Transduction
Smooth muscle
Urinary Bladder - metabolism
Urinary Bladder - pathology
Urinary Bladder Diseases - metabolism
Urogenital system
Urothelium
Urothelium - metabolism
Urothelium - pathology
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Summary:The urothelium was long considered to be a silent barrier protecting the body from the toxic effects of urine. However, today a number of dynamic abilities of the urothelium are well recognized, including its ability to act as a sensor of the intravesical environment. During recent years several pathways of these urothelial abilities have been proposed and a major part of these pathways includes release of signalling molecules. It is now evident that the urothelium represents only one part of the sensory web. Urinary bladder signalling is finely tuned machinery of signalling molecules, acting in autocrine and paracrine manner, and their receptors are specifically distributed among different types of cells in the urinary bladder. In the present review the current knowledge of the formation, release, and signalling effects of urothelial acetylcholine, ATP, adenosine, and nitric oxide in health and disease is discussed.
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2014/297295