Presynaptic actions of transcranial and local direct current stimulation in the red nucleus

Key points Transcranial direct current stimulation (tDCS) may affect both postsynaptic neurons and presynaptic axons providing input to these neurons. Here, we show that presynaptic subcortical actions of tDCS outlast the duration of its application by up to 1 h and may contribute to long‐lasting fa...

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Bibliographic Details
Published in:The Journal of physiology 2014-10, Vol.592 (19), p.4313-4328
Main Authors: Bączyk, M., Jankowska, E.
Format: Article
Language:English
Subjects:
Animals
Basic Medicine
Brain
Cats
Electromyography
Evoked Potentials, Motor - physiology
Female
Male
Medicinska grundvetenskaper
Neck Muscles - physiology
Neurons - physiology
Neuroscience: Development/Plasticity/Repair
Presynaptic Terminals - physiology
Rats
Rats, Wistar
Red Nucleus - physiology
Transcranial Direct Current Stimulation - methods
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Summary:Key points Transcranial direct current stimulation (tDCS) may affect both postsynaptic neurons and presynaptic axons providing input to these neurons. Here, we show that presynaptic subcortical actions of tDCS outlast the duration of its application by up to 1 h and may contribute to long‐lasting facilitation of activation of neurons in the red nucleus in experiments on deeply anaesthetized animals. This is demonstrated by increased axonal excitability of the interpositorubral neurons that, in turn, activate rubrospinal neurons. We also show that effects of electric fields induced by tDCS may be reproduced by local cathodal polarization, by applying
ISSN:0022-3751
1469-7793
1469-7793
DOI:10.1113/jphysiol.2014.276691