Renal function in adult women with urinary tract infection in childhood

Background The risk of deterioration of renal function in patients with urinary tract infection (UTI)-associated renal damage over several decades is incompletely known but of importance in regard to follow-up. Methods A population-based cohort of women followed from their first UTI in childhood was...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2015-09, Vol.30 (9), p.1493-1499
Main Authors: Gebäck, Carin, Hansson, Sverker, Martinell, Jeanette, Sandberg, Torsten, Sixt, Rune, Jodal, Ulf
Format: Article
Language:English
Subjects:
Acids
Adult
Adults
Age
Bacterial infections
Blood pressure
Care and treatment
Child
Chronic kidney disease
Demographic aspects
DMSA scan
Female
Glomerular Filtration Rate
Health aspects
Hospitals
Humans
Hypertension
Infectious diseases
Investigations
Kidney - diagnostic imaging
Kidney - physiopathology
Kidney diseases
Longitudinal Studies
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Original Article
Patient outcomes
Pediatrics
Pediatrik
Radiography
Radiopharmaceuticals - pharmacology
Renal damage
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - etiology
Renal Insufficiency, Chronic - physiopathology
Risk factors
Severity of Illness Index
Sweden - epidemiology
Technetium Tc 99m Dimercaptosuccinic Acid - pharmacology
Urinary tract diseases
Urinary tract infections
Urinary Tract Infections - complications
Urinary Tract Infections - epidemiology
Urogenital system
Urology
Womens health
Young women
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Summary:Background The risk of deterioration of renal function in patients with urinary tract infection (UTI)-associated renal damage over several decades is incompletely known but of importance in regard to follow-up. Methods A population-based cohort of women followed from their first UTI in childhood was studied at median age of 27 years and now at 41 years. Renal damage was evaluated by 99m Tc-dimercaptosuccinic acid scan and glomerular filtration rate (GFR) by 51 Cr-edetic acid clearance. Extent of individual kidney damage was graded as class 1 to 3. Results Eighty-six women completed the investigation, 58 with renal damage, and 28 without. Of those with damage, one had chronic kidney disease (CKD) stage 3, 14 stage 2, and 43 stage 1. Women with bilateral damage had lower GFR than those with no or unilateral damage ( p  
ISSN:0931-041X
1432-198X
1432-198X
DOI:10.1007/s00467-015-3084-8