Striatal tyrosine hydroxylase-positive neurons are associated with l -DOPA-induced dyskinesia in hemiparkinsonian mice

• Published in: Neuroscience 2015-07, Vol.298, p.302-317
• Main Authors: Keber, U, Klietz, M, Carlsson, T, Oertel, W.H, Weihe, E, Schäfer, M.K.-H, Höglinger, G.U, Depboylu, C
• Format: Article
• Language: English
• Subjects: 1989; 1994; abnormal involuntary movement; accumbens; Amphetamine - pharmacology; Animals; Antiparkinson Agents - adverse effects; Corpus Striatum - pathology; DELTA-FOSB; Disease Models, Animal; dopamine; DOPAMINERGIC-NEURONS; Dyskinesia, Drug-Induced - etiology; Dyskinesia, Drug-Induced - pathology; FOSB EXPRESSION; Functional Laterality - physiology; FUNCTIONAL-SIGNIFICANCE; IMMUNOREACTIVE NEURONS; INSSEN EPM; JOURNAL OF NEUROSCIENCE; Levodopa - adverse effects; LEVODOPA-INDUCED DYSKINESIAS; Male; Medial Forebrain Bundle - drug effects; Medial Forebrain Bundle - injuries; Mice; Mice, Inbred C57BL; Neurology; Neurons - metabolism; NEUROSCIENCE LETTERS; Neurosciences; Neurovetenskaper; NUCLEUS-ACCUMBENS; Oxidopamine - toxicity; P1555; Parkinson Disease - drug therapy; Parkinson Disease - etiology; Parkinson's disease; PARKINSONS-DISEASE PATIENTS; Phosphopyruvate Hydratase - metabolism; Proto-Oncogene Proteins c-fos - metabolism; RAT MODEL; Serotonin Plasma Membrane Transport Proteins - metabolism; SHIRO Y; Statistics, Nonparametric; striatum; Tyrosine 3-Monooxygenase - metabolism; UP-REGULATION; V14; V97
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.04.021

Highlights • Striatal TH+ neurons correlated positively with AIMs and striatal ΔFosB expression. • Striatal serotonergic innervation was increased in dyskinetic mice. • Striatal TH+ cells and serotonergic terminals may cooperatively synthesize dopamine. • The lateral striatum represents a key region of neuronal plasticity in LID. • AIM subtypes correlated with the distribution of TH+ neurons in striatal subregions.