High Recovery Rate of Non-albicans Candida Species Isolated From Burn Patients With Candidemia in Iran

Blood stream infections (BSIs) are major causes of morbidity and mortality in burn patients. Microorganisms responsible for BSI are generally bacteria; however, Candida spp. are the infection agents in as many as 8% of all cases. Burn wound colonization and infections are generally the first steps t...

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Bibliographic Details
Published in:Jundishapur journal of microbiology 2015-10, Vol.8 (10), p.e22929-e22929
Main Authors: Lotfi, Nazanin, Shokohi, Tahereh, Nouranibaladezaei, Seyed Zahra, Nasrolahi Omran, Ayatollah, Kondori, Nahid
Format: Article
Language:English
Subjects:
Burn Patients
Burns
Candida
Candidemia
Diagnosis
In vitro Antifungal Susceptibility
Infectious Medicine
Infektionsmedicin
Iran
Non-albicans Candida
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Summary:Blood stream infections (BSIs) are major causes of morbidity and mortality in burn patients. Microorganisms responsible for BSI are generally bacteria; however, Candida spp. are the infection agents in as many as 8% of all cases. Burn wound colonization and infections are generally the first steps to systemic infection. Candidemia in burn patients has been associated with high mortality and a prolonged hospital stay. Candidemia in burn patients has been defined as a preterminal event, leading to high morbidity and mortality rates among these patients. The aim of this study was to establish the incidence of candidemia in burn patients in Iran. We consecutively collected 405 blood samples from 113 burn patients. The yeast isolates were identified to the species level using conventional procedures. In vitro antifungal susceptibility of the Candida isolates to amphotericin B, fluconazole, voriconazole and caspofungin was performed using the Etest. Twenty-seven samples (6.7%) of the blood cultures from 13 patients (12%) were positive for Candida species. Candida parapsilosis (38%) and C. tropicalis (38%) were the most commonly found Candida species, followed by C. albicans (15%) and C. guilliermondii (15%) in the patients. The incidence of candidemia was significantly correlated with increased duration of hospitalization, increased time of stay in the intensive care unit, and higher mortality. The antifungal susceptibility tests demonstrated that amphotericin B and voriconazole had the lowest minimum inhibitory concentrations (MICs) against Candida spp. Non-albicans Candida should be considered as significant pathogens in burned patients with candidemia.
ISSN:2008-3645
2008-4161
DOI:10.5812/jjm.22929