Oral microbiota in patients with atherosclerosis

Abstract Background and aims Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is sugg...

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Bibliographic Details
Published in:Atherosclerosis 2015-12, Vol.243 (2), p.573-578
Main Authors: Fåk, Frida, Tremaroli, Valentina, Bergström, Göran, Bäckhed, Fredrik
Format: Article
Language:English
Subjects:
Aged
Asymptomatic Diseases
Atherosclerosis
Bacteria - classification
Bacteria - genetics
Bacteria - isolation & purification
Cardiovascular
Carotid Arteries - pathology
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - microbiology
Case-Control Studies
Clinical Medicine
Discriminant Analysis
Female
Humans
Klinisk medicin
Linear Models
Male
Microbiota
Middle Aged
Mouth - microbiology
Oral microbiota
Plaque, Atherosclerotic
Pyrosequencing
Ribotyping
Risk Factors
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Summary:Abstract Background and aims Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques. Methods To elucidate whether the oral microbiota composition differed between patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including patients with asymptomatic and symptomatic atherosclerosis and control individuals without carotid plaques or previous stroke or myocardial infarction. Results The overall microbial structure was similar in controls and atherosclerosis patients, but patients with symptomatic atherosclerosis had higher relative abundance of Anaeroglobus (mean 0.040% (SD 0.049)) than the control group (0.010% (SD 0.028)) ( P  = 0.03). Using linear regression analysis, we found that Parvimonas associated positively with uCRP and Capnocytophaga , Catonella and Lactobacillus associated with blood lipid markers. In conclusion, abundance of Anaeroglobus in the oral cavity could be associated with symptomatic atherosclerosis.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.10.097