Diagnosing Dementia in the Clinical Setting: Can Amyloid PET Provide Additional Value Over Cerebrospinal Fluid?

Cerebrospinal fluid (CSF) measures of amyloid and tau are the first-line Alzheimer’s disease biomarkers in many clinical centers. We assessed if and when the addition of amyloid PET following CSF measurements provides added diagnostic value. Twenty patients from a cognitive clinic, who had undergone...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2016-10, Vol.54 (4), p.1297-1302
Main Authors: Weston, Philip S.J., Paterson, Ross W., Dickson, John, Barnes, Anna, Bomanji, Jamshed B., Kayani, Irfan, Lunn, Michael P., Mummery, Catherine J., Warren, Jason D., Rossor, Martin N., Fox, Nick C., Zetterberg, Henrik, Schott, Jonathan M.
Format: Article
Language:English
Subjects:
Aged
Amyloid beta-Peptides - cerebrospinal fluid
Biomarkers - cerebrospinal fluid
Dementia - cerebrospinal fluid
Dementia - diagnostic imaging
Female
Humans
Male
Middle Aged
Neurosciences
Neurovetenskaper
Peptide Fragments - cerebrospinal fluid
Positron-Emission Tomography - standards
Short Communication
tau Proteins - cerebrospinal fluid
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Summary:Cerebrospinal fluid (CSF) measures of amyloid and tau are the first-line Alzheimer’s disease biomarkers in many clinical centers. We assessed if and when the addition of amyloid PET following CSF measurements provides added diagnostic value. Twenty patients from a cognitive clinic, who had undergone detailed assessment including CSF measures, went on to have amyloid PET. The treating neurologist’s working diagnosis, and degree of diagnostic certainty, was assessed both before and after the PET. Amyloid PET changed the diagnosis in 7/20 cases. Amyloid PET can provide added diagnostic value, particularly in young-onset, atypical dementias, where CSF results are borderline and diagnostic uncertainty remains.
ISSN:1387-2877
1875-8908
1875-8908
DOI:10.3233/JAD-160302