Sympathetic neural burst amplitude distribution: A more specific indicator of sympathoexcitation in human heart failure

Human muscle sympathetic nerve activity (MSNA) is usually measured as the number of pulse-synchronous bursts in multiunit mean voltage recordings. We recently suggested burst amplitude distribution as a more sensitive indicator of altered MSNA in congestive heart failure (CHF). Here, we test whether...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-10, Vol.102 (17), p.2076-2081
Main Authors: SVERRISDOTTIR, Yrsa Bergmann, RUNDQVIST, Bengt, JOHANNSSON, Gudmundur, ELAM, Mikael
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
Biological and medical sciences
Cardiology. Vascular system
Endocrinology and Diabetes
Endokrinologi och diabetes
Female
Fysiologi
Heart
Heart Failure
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Hypopituitarism
Hypopituitarism - physiopathology
Male
Medical sciences
Middle Aged
Muscle Fibers
Muscle Fibers, Skeletal
Physiology
physiopathology
Skeletal
Sympathetic Nervous System
Sympathetic Nervous System - physiopathology
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Summary:Human muscle sympathetic nerve activity (MSNA) is usually measured as the number of pulse-synchronous bursts in multiunit mean voltage recordings. We recently suggested burst amplitude distribution as a more sensitive indicator of altered MSNA in congestive heart failure (CHF). Here, we test whether this distribution can discriminate between different conditions with increased MSNA burst frequency and whether it reflects single vasoconstrictor fiber firing intensity. We analyzed resting multiunit MSNA in 36 CHF patients (24 with mild to moderate CHF, 12 with severe CHF investigated before and after heart transplantation), 14 patients with pituitary deficiency, 25 matched healthy control subjects, and an additional 56 healthy men with a wider age range (21 to 71 years). Pituitary deficiency was associated with increased MSNA burst frequency (60 versus 37 bursts/min in control subjects), equivalent to that in mild to moderate CHF (61 bursts/min). However, burst amplitude distribution in hypopituitary patients (median burst amplitude, 37%) did not deviate from matched control subjects (36%), whereas amplitudes increased with disease severity in CHF (43% in mild to moderate, 52% in severe) and normalized after transplantation (36%). In the larger healthy group, MSNA burst frequency increased with age, and burst amplitude distribution remained unaffected. In 8 CHF patients, single-unit firing frequency showed a close positive relationship to multiunit burst amplitude distribution (r=0.82, P:
ISSN:0009-7322
1524-4539
1524-4539
DOI:10.1161/01.CIR.102.17.2076