Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases

Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for preventing the accumulation of misfolded proteins. SGs, however, have been linked to the pathogenesis of neurodegenerative diseases, in part because SGs share many components with neuronal granules. Oxidative st...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Chen, Lihua, Liu, Beidong
Format: Article
Language:English
Subjects:
Alzheimer's disease
alzheimers-disease
amyotrophic-lateral-sclerosis
Animals
Antioxidants
Biological Sciences
Biologiska vetenskaper
Biology
Cell Biology
Cells
Cellular signal transduction
Chemical Sciences
Cytoplasmic Granules - metabolism
Degeneration
dna-binding
Glucose
heat-stress
Humans
hydrogen-peroxide
Kemi
Mammals
Mutation
Nervous system
Neurodegeneration
Neurodegenerative Diseases - metabolism
Oxidative stress
Oxidative Stress - physiology
p-bodies
parkinsons-disease
polyadenylated messenger-rna
protein
Proteins
Review
Rodents
saccharomyces-cerevisiae
Transcription factors
translational repression
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Summary:Cytoplasmic stress granules (SGs) are critical for facilitating stress responses and for preventing the accumulation of misfolded proteins. SGs, however, have been linked to the pathogenesis of neurodegenerative diseases, in part because SGs share many components with neuronal granules. Oxidative stress is one of the conditions that induce SG formation. SGs regulate redox levels, and SG formation in turn is differently regulated by various types of oxidative stress. These associations and other evidences suggest that SG formation contributes to the development of neurodegenerative diseases. In this paper, we review the regulation of SG formation/assembly and discuss the interactions between oxidative stress and SG formation. We then discuss the links between SGs and neurodegenerative diseases and the current therapeutic approaches for neurodegenerative diseases that target SGs.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/1809592