Prediction of neonatal respiratory morbidity by quantitative ultrasound lung texture analysis: a multicenter study

• Published in: American journal of obstetrics and gynecology 2017-08, Vol.217 (2), p.196.e1-196.e14
• Main Authors: Palacio, Montse, MD, PhD, Bonet-Carne, Elisenda, MSc, PhD, Cobo, Teresa, MD, PhD, Perez-Moreno, Alvaro, MSc, Sabrià, Joan, MD, PhD, Richter, Jute, MD, PhD, Kacerovsky, Marian, MD, PhD, Jacobsson, Bo, MD, PhD, García-Posada, Raúl A., MD, Bugatto, Fernando, MD, PhD, Santisteve, Ramon, MD, Vives, Àngels, MD, Parra-Cordero, Mauro, MD, PhD, Hernandez-Andrade, Edgar, MD, PhD, Bartha, José Luis, MD, PhD, Carretero-Lucena, Pilar, MD, Tan, Kai Lit, MRCOG, Cruz-Martínez, Rogelio, MD, PhD, Burke, Minke, MD, Vavilala, Suseela, MD, Iruretagoyena, Igor, MD, Delgado, Juan Luis, MD, PhD, Schenone, Mauro, MD, Vilanova, Josep, MD, PhD, Botet, Francesc, MD, PhD, Yeo, George S.H., FRCOG, Hyett, Jon, MD, PhD, Deprest, Jan, MD, PhD, Romero, Roberto, MD, DMedSci, Gratacos, Eduard, MD, PhD
• Format: Article
• Language: English
• Subjects: Adult; amniocentesis; amniotic fluid analysis; biomarker; Complicacions en l'embaràs; Complications of pregnancy; computational methods; diagnostic indices; Embaràs; Female; fetal lung maturity; Humans; Infant, Newborn; Lung - diagnostic imaging; Lung - embryology; Lung - pathology; Malalties dels pulmons; Male; Morbiditat; Morbidity; neonatal respiratory morbidity; Neonatologia; Neonatology; Obstetrics and Gynecology; Obstetrics, Gynecology and Reproductive Medicine; Predictive Value of Tests; predictive values; Pregnancy; Prospective Studies; Pulmonary diseases; quantitative texture analysis; Reproduktionsmedicin och gynekologi; respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - epidemiology; sonography; Tachypnea - epidemiology; transient tachypnea; Ultrasonography, Prenatal; ultrasound
• ISSN: 0002-9378; 1097-6868; 1097-6868
• DOI: 10.1016/j.ajog.2017.03.016

Background Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure restricts the use of fetal lung maturity assessment. Objective The objective of the study was to evaluate the performance of quantitative ultrasound texture analysis of the fetal lung (quantusFLM) to predict neonatal respiratory morbidity in preterm and early-term (