Cerebrospinal fluid markers of neuronal and glial cell damage in patients with autoimmune neurologic syndromes with and without underlying malignancies

Abstract Autoimmune neurologic syndromes can be paraneoplastic (associated with malignancies and/or onconeural antibodies), or non-paraneoplastic. Their clinical presentation is often similar. As prognosis is related to malignancy treatment, better biomarkers are needed to identify patients with mal...

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Bibliographic Details
Published in:Journal of neuroimmunology 2017-05, Vol.306, p.25-30
Main Authors: Constantinescu, Radu, Krýsl, David, Andrén, Kerstin, Asztély, Fredrik, Bergquist, Filip, Zetterberg, Henrik, Andreasson, Ulf, Axelsson, Markus, Menachem, Elinor Ben, Jons, Daniel, Mahamud, Ubah, Malmeström, Clas, Rosengren, Lars, Blennow, Kaj
Format: Article
Language:English
Subjects:
Allergy and Immunology
Autoimmune Diseases of the Nervous System - cerebrospinal fluid
Autoimmune Diseases of the Nervous System - complications
Autoimmune Diseases of the Nervous System - diagnostic imaging
Autoimmune encephalitis
Autoimmune neurological syndrome
Biomarkers - cerebrospinal fluid
Brain - diagnostic imaging
Brain - pathology
Child
Child, Preschool
Electroencephalography
Female
Humans
Magnetic Resonance Imaging
Male
Neoplasms - cerebrospinal fluid
Neoplasms - complications
Neoplasms - diagnostic imaging
Nerve Tissue Proteins - cerebrospinal fluid
Neurofilament light chain
Neurology
Neurosciences
Neurovetenskaper
Non-paraneoplastic
Paraneoplastic neurologic syndrome
Retrospective Studies
Statistics, Nonparametric
Tau protein
tau Proteins - cerebrospinal fluid
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Summary:Abstract Autoimmune neurologic syndromes can be paraneoplastic (associated with malignancies and/or onconeural antibodies), or non-paraneoplastic. Their clinical presentation is often similar. As prognosis is related to malignancy treatment, better biomarkers are needed to identify patients with malignancy. We investigated cerebrospinal fluid (CSF) markers of neuronal (neurofilament light chain, NFL and total tau protein, T-tau) and glial (glial fibrillary acidic protein) damage. CSF-NFL and T-tau were increased in both paraneoplastic and non-paraneoplastic autoimmune syndromes. Patients with manifest malignancies were older, had less epilepsy, more focal central and peripheral neurological signs and symptoms, and worse long-term outcome, than those without malignancy. CSF-NFL-levels predicted long-term outcome but were not diagnostic for malignancy, after age adjustment.
ISSN:0165-5728
1872-8421
1872-8421
DOI:10.1016/j.jneuroim.2017.02.018