Bone tissue response following local drug delivery of bisphosphonate through titanium oxide nanotube implants in a rabbit model

Objectives The objective of this study was to evaluate whether surface chemistry‐controlled TiO2 nanotube structures may serve as a local drug delivery system for zoledronic acid improving implant‐bone support. Methods Twenty‐four screw‐shaped Ti implants with surface chemistry‐controlled TiO2 nanot...

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Bibliographic Details
Published in:Journal of clinical periodontology 2017-09, Vol.44 (9), p.941-949
Main Authors: Kwon, David H., Lee, Sang J., Wikesjö, Ulf M. E., Johansson, Petra H., Johansson, Carina B., Sul, Young‐Taeg
Format: Article
Language:English
Subjects:
Animals
bisphosphonate
bone
Bone growth
Bone implants
Dental Implantation, Endosseous
Dental Implants
Dentistry
Diphosphonates - administration & dosage
Drug delivery
Drug Delivery Systems
Drug development
Femur
Femur - surgery
Imidazoles - administration & dosage
Implants, Experimental
local drug delivery system
Male
Microscopy, Electron, Scanning
Nanotubes
Odontologi
Odontology
Osseointegration
Osseointegration - physiology
Osteogenesis
Rabbits
Resonance Frequency Analysis
Surface chemistry
Titanium
Titanium - pharmacology
titanium implant
Titanium oxide
Torque
Transplants & implants
Zoledronic acid
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Summary:Objectives The objective of this study was to evaluate whether surface chemistry‐controlled TiO2 nanotube structures may serve as a local drug delivery system for zoledronic acid improving implant‐bone support. Methods Twenty‐four screw‐shaped Ti implants with surface chemistry‐controlled TiO2 nanotube structures were prepared and divided into a zoledronic acid‐formatted test and a native control group. The implants were inserted into contra‐lateral femoral condyles in 12 New Zealand White rabbits. Bone support was evaluated using resonance frequency analysis (RFA) and removal torque (RTQ), as well as histometric analysis following a 3‐weeks healing interval. Results Zoledronic acid‐formatted TiO2 nanotube test implants showed significantly improved implant stability and osseointegration measured using RFA and RTQ compared with control (p 
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.12776