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ALCOHOLICS WITH THE DOPAMINE RECEPTOR DRD2 A1 ALLELE HAVE LOWER PLATELET MONOAMINE OXIDASE-B ACTIVITY THAN THOSE WITH THE A2 ALLELE: A PRELIMINARY STUDY

Low platelet monoamine oxidase B (MAO-B) activity and the presence of the Taq1 A1 allele of the dopamine D2 receptor (DRD2) gene have independently been proposed as ‘biological/genetic’ markers for alcoholism. In the present study, the relationship between these two markers was investigated in a gro...

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Published in:Alcohol and alcoholism (Oxford) 2000-09, Vol.35 (5), p.493-498
Main Authors: Eriksson, Matts, Berggren, Ulf, Blennow, Kaj, Fahlke, Claudia, Månsson, Jan-Erik, Balldin, Jan
Format: Article
Language:English
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Summary:Low platelet monoamine oxidase B (MAO-B) activity and the presence of the Taq1 A1 allele of the dopamine D2 receptor (DRD2) gene have independently been proposed as ‘biological/genetic’ markers for alcoholism. In the present study, the relationship between these two markers was investigated in a group of socially stable Caucasian middle-aged men with a mean (±SD) daily ethanol consumption of 85 ± 57 g. The platelet MAO-B activity was significantly lower in individuals with the DRD2 A1 allele (n = 8), compared to those without it (n = 29). This relationship remained unchanged when including only subjects who fulfilled DSM-IV criteria for alcohol dependence (n = 27). The finding suggests that alcoholics who are carriers of the DRD2 A1 allele may have lower platelet MAO-B activity.
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/alcalc/35.5.493