Cracking the Sugar Code by Mass Spectrometry

The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensi...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2018-06, Vol.29 (6), p.1065-1074
Main Authors: Mirgorodskaya, Ekaterina, Karlsson, Niclas G., Sihlbom, Carina, Larson, Göran, Nilsson, Carol L.
Format: Article
Language:English
Subjects:
assisted laser-desorption
Biochemistry & Molecular Biology
Biochemistry and Molecular Biology
Biokemi och molekylärbiologi
Cellular structure
Chemistry
Clinical Laboratory Medicine
electron-capture dissociation
fast-atom-bombardment
Glycan
Glycan mass spectrometry
glycomics experiment
glycosylation sites
History of mass spectrometry
Homeostasis
Klinisk laboratoriemedicin
Magnetic resonance spectroscopy
Mass spectrometry
NMR
Nuclear magnetic resonance
oligosaccharides
permethylated
post-source decay
Review
Scientific imaging
spectral characterization
Spectroscopy
Structural mass spectrometry
structural-characterization
trichomonas-vaginalis
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Summary:The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensitivity. The patterns of such structures in different cellular states now allow us to interpret the sugar codes in health and disease, based on structure-function relationships. Dr. Catherine E. Costello was the 2017 recipient of the American Society for Mass Spectrometry’s Distinguished Contribution Award. In this Perspective article, we describe her seminal work in a historical and geographical context and review the impact of her research accomplishments in the field.8
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-018-1912-3