Explorative study on quality of life in relation to salivary secretion rate in head and neck cancer patients treated with radiotherapy up to 2 years post treatment

Objective The aim of this study was to analyse quality of life (QoL) pretreatment and up to 24 months post radiation therapy (RT) in patients with head and neck (H&N) cancer. Methods Twenty‐nine patients (19 men and 10 women) with a mean age of 59 ± 8 years were included. The stimulated salivary...

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Bibliographic Details
Published in:International journal of dental hygiene 2019-02, Vol.17 (1), p.46-54
Main Authors: Almståhl, Annica, Skoogh Andersson, Jessica, Alstad, Torgny, Fagerberg‐Mohlin, Bodil, Finizia, Caterina
Format: Article
Language:English
Subjects:
Aged
Anxiety
Cancer
Cancer therapies
Dentistry
Female
Follow-Up Studies
Head & neck cancer
head and neck cancer
Head and Neck Neoplasms - complications
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - physiopathology
Head and Neck Neoplasms - radiotherapy
Humans
hyposalivation
Insomnia
Male
Mental depression
Middle Aged
Oto-rino-laryngologi
Otorhinolaryngology
Patients
Quality of Life
Radiation therapy
Saliva
Saliva - metabolism
salivary secretion rate
Secretion
Sleep disorders
Statistical analysis
Surveys and Questionnaires
Swallowing
Time Factors
Xerostomia - etiology
Xerostomia - metabolism
Xerostomia - physiopathology
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Summary:Objective The aim of this study was to analyse quality of life (QoL) pretreatment and up to 24 months post radiation therapy (RT) in patients with head and neck (H&N) cancer. Methods Twenty‐nine patients (19 men and 10 women) with a mean age of 59 ± 8 years were included. The stimulated salivary secretion was measured and the patients completed the European Organisation for Research and Treatment of Cancer Quality of Life questionnaires (EORTC QLQ‐C30 and H&N35) and the Hospital Anxiety and Depression scale (HADS) pretreatment and at 6, 12 and 24 months post RT. Results At all time‐points after RT (6, 12, and 24 months), patients with hyposalivation (stimulated secretion rate ≤0.7 mL/min) reported clinically significant differences (> 10 points) regarding insomnia, swallowing, social eating, dry mouth, and sticky saliva. Statistically significant differences were found for emotional functioning and insomnia at 12 months (P 
ISSN:1601-5029
1601-5037
1601-5037
DOI:10.1111/idh.12363