Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the pr...

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Bibliographic Details
Published in:Journal of extracellular vesicles 2018-12, Vol.7 (1), p.1473707-n/a
Main Authors: Clayton, Aled, Buschmann, Dominik, Byrd, J. Brian, Carter, David R. F., Cheng, Lesley, Compton, Carolyn, Daaboul, George, Devitt, Andrew, Falcon-Perez, Juan Manuel, Gardiner, Chris, Gustafson, Dakota, Harrison, Paul, Helmbrecht, Clemens, Hendrix, An, Hill, Andrew, Hoffman, Andrew, Jones, Jennifer C., Kalluri, Raghu, Kang, Ji Yoon, Kirchner, Benedikt, Lässer, Cecilia, Lawson, Charlotte, Lenassi, Metka, Levin, Carina, Llorente, Alicia, Martens-Uzunova, Elena S., Möller, Andreas, Musante, Luca, Ochiya, Takahiro, Pink, Ryan C, Tahara, Hidetoshi, Wauben, Marca H. M., Webber, Jason P., Welsh, Joshua A., Witwer, Kenneth W., Yin, Hang, Nieuwland, Rienk
Format: Article
Language:English
Subjects:
Biomarkers
Body fluids
Cancer
Cell and Molecular Biology
Cell- och molekylärbiologi
Compliance
exosomes
Extracellular vesicles
HIV
Human immunodeficiency virus
Laboratories
Medical research
Meeting Report
Mutation
Pancreatic cancer
plasma
Reproducibility
Researchers
serum
Studies
Urine
Variables
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Summary:This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
ISSN:2001-3078
2001-3078
DOI:10.1080/20013078.2018.1473707