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Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)

Background One‐fifth of patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) have invasive breast cancer (IBC) on definitive histology. Sentinel lymph node dissection (SLND) is performed in almost half of women having surgery for DCIS in Sweden. The aim of the present study was...

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Bibliographic Details
Published in:British journal of surgery 2019-05, Vol.106 (6), p.720-728
Main Authors: Karakatsanis, A., Hersi, A.‐F., Pistiolis, L., Olofsson Bagge, R., Lykoudis, P. M., Eriksson, S., Wärnberg, F., Nagy, G., Mohammed, I., Sundqvist, M., Bergkvist, L., Kwong, A., Olofsson, H., Stålberg, P.
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Language:English
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Summary:Background One‐fifth of patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) have invasive breast cancer (IBC) on definitive histology. Sentinel lymph node dissection (SLND) is performed in almost half of women having surgery for DCIS in Sweden. The aim of the present study was to try to minimize unnecessary SLND by injecting superparamagnetic iron oxide (SPIO) nanoparticles at the time of primary breast surgery, enabling SLND to be performed later, if IBC is found in the primary specimen. Methods Women with DCIS at high risk for the presence of invasion undergoing breast conservation, and patients with DCIS undergoing mastectomy were included. The primary outcome was whether this technique could reduce SLND. Secondary outcomes were number of SLNDs avoided, detection rate and procedure‐related costs. Results This was a preplanned interim analysis of 189 procedures. IBC was found in 47 and a secondary SLND was performed in 41 women. Thus, 78·3 per cent of patients avoided SLND (P 
ISSN:0007-1323
1365-2168
1365-2168
DOI:10.1002/bjs.11110