Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO th...

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Bibliographic Details
Published in:Clinical and experimental allergy 2019-07, Vol.49 (7), p.969-979
Main Authors: Nerpin, Elisabet, Olivieri, Mario, Gislason, Thorainn, Olin, Anna C., Nielsen, Rune, Johannessen, Ane, Ferreira, Diogenes S., Marcon, Alessandro, Cazzoletti, Lucia, Accordini, Simone, Pin, Isabelle, Corsico, Angelo, Demoly, Pascal, Weyler, Joost, Nowak, Dennis, Jõgi, Rain, Forsberg, Bertil, Zock, Jan P., Sigsgaard, Torben, Heinric, Joachim, Bono, Roberto, Leynaert, Bénédicte, Jarvis, Deborah, Janson, Christer, Malinovschi, Anderi
Format: Article
Language:English
Subjects:
Adult
Age
Aged
airway
Allergens
Allergology
Allergy
Asthma
Asthma - diagnosis
Asthma - metabolism
atopy
Breath Tests
children
Cross-Sectional Studies
European Union
Exhalation
Female
FENO
Follow-Up Studies
fractional exhaled nitric oxide
Health and Welfare
Health Surveys
healthy population
height
Human health and pathology
Humans
Hälsa och välfärd
IgE sensitization
Immunoglobulin E
Immunology
Life Sciences
Lung diseases
Lungmedicin och allergi
Male
Middle Aged
Nitric oxide
Nitric Oxide - metabolism
people
Polls & surveys
population
Pulmonology and respiratory tract
reference values
Respiratory Medicine and Allergy
Santé publique et épidémiologie
Smoking
Surveys and Questionnaires
Womens health
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Summary:Introduction The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective To identify determinants of FENO in men and women without lung diseases. Method Fractional exhaled nitric oxide was validly measured in 3881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease. Results Exhaled NO levels were 21.3% higher in men compared with women P 
ISSN:0954-7894
1365-2222
1365-2222
DOI:10.1111/cea.13394