The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

[Display omitted] The adsorption of proteins is the initiating event in the processes occurring when blood contacts a “foreign” surface in a medical device, leading inevitably to thrombus formation. Knowledge of protein adsorption in this context has accumulated over many years but remains fragmenta...

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Bibliographic Details
Published in:Acta biomaterialia 2019-08, Vol.94, p.11-24
Main Authors: Brash, John L., Horbett, Thomas A., Latour, Robert A., Tengvall, Pentti
Format: Article
Language:English
Subjects:
Adsorption
Animals
Annan materialteknik
Antifouling
Biocompatibility
Biocompatible Materials
Biomaterials
Biomaterials Science
Biomaterialvetenskap
Biomedical materials
Blood
Blood Coagulation
Blood compatibility
Blood Platelets - metabolism
Blood Proteins - chemistry
Coagulation
Complement Activation
Composition effects
Denaturation
Fibrinogen - metabolism
Humans
Materials Testing
Medical devices
Medical electronics
Medical equipment
Other Materials Engineering
Platelet Adhesiveness
Protein adsorption
Protein Binding
Protein composition
Protein Conformation
Protein denaturation
Proteins
Surface
Surface Properties
Thrombosis
Thrombosis - metabolism
Thrombosis - prevention & control
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Summary:[Display omitted] The adsorption of proteins is the initiating event in the processes occurring when blood contacts a “foreign” surface in a medical device, leading inevitably to thrombus formation. Knowledge of protein adsorption in this context has accumulated over many years but remains fragmentary and incomplete. Moreover, the significance and relevance of the information for blood compatibility are not entirely agreed upon in the biomaterials research community. In this review, protein adsorption from blood is discussed under the headings “agreed upon” and “not agreed upon or not known” with respect to: protein layer composition, effects on coagulation and complement activation, effects on platelet adhesion and activation, protein conformational change and denaturation, prevention of nonspecific protein adsorption, and controlling/tailoring the protein layer composition. This paper is part 2 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity. The objective was to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute. We hope that future investigators will update these reviews as new scholarship resolves the uncertainties of today.
ISSN:1742-7061
1878-7568
1878-7568
DOI:10.1016/j.actbio.2019.06.022