Serum Neurofilament Light Chain Concentration Correlates with Infarct Volume but Not Prognosis in Acute Ischemic Stroke

Background and Purpose: We studied serum neurofilaments diagnostic value in patients with acute ischemic stroke (AIS) or TIA and evaluated any correlation with symptom severity, cerebral infarction volume, aetiology, and clinical outcome. Methods: One hundred and thirty-six patients (101 with AIS, a...

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Published in:Journal of stroke and cerebrovascular diseases 2019-08, Vol.28 (8), p.2242-2249
Main Authors: Onatsu, Juha, Vanninen, Ritva, Jäkälä, Pekka, Mustonen, Pirjo, Pulkki, Kari, Korhonen, Miika, Hedman, Marja, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina, Herukka, Sanna-Kaisa, Taina, Mikko
Format: Article
Language:English
Subjects:
biomarker
biomarkers
Cardiovascular System & Cardiology
cerebrospinal-fluid
Ischemic
light
neurofilament
Neurosciences
Neurosciences & Neurology
Neurovetenskaper
protein
Simoa
stroke
TIA
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Summary:Background and Purpose: We studied serum neurofilaments diagnostic value in patients with acute ischemic stroke (AIS) or TIA and evaluated any correlation with symptom severity, cerebral infarction volume, aetiology, and clinical outcome. Methods: One hundred and thirty-six patients (101 with AIS, and 35 with TIA) were included. Acute-phase serum neurofilament light chain (sNfL) was analyzed with a novel ultrasensitive single molecule array (Simoa). Cerebral infarction volume was measured from brain computed tomography in the subacute phase (>2 days). Stroke aetiology was defined by trial of ORG 10172 in acute stroke treatment classification, severity by National Institute of Health stroke scale (NIHSS) and the degree of disability by the Modified Rankin Scale (mRS) after 90 days. Results: sNfL was markedly higher in patients with AIS (89.5 pg/mL [IQR: 44.7-195.3]) than with TIA (25.2 pg/mL [IQR: 14.6-48.0]), P=
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2019.05.008