Analysis of the bone ultrastructure around biodegradable Mg–xGd implants using small angle X-ray scattering and X-ray diffraction

Magnesium alloys are increasingly researched as temporary biodegradable metal implants in bone applications due to their mechanical properties which are more similar to bone than conventional implant metals and the fact that Magnesium occurs naturally within the body. However, the degradation proces...

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Bibliographic Details
Published in:Acta biomaterialia 2020-01, Vol.101 (1), p.637-645
Main Authors: Zeller-Plumhoff, Berit, Malich, Carina, Krüger, Diana, Campbell, Graeme, Wiese, Björn, Galli, Silvia, Wennerberg, Ann, Willumeit-Römer, Regine, Wieland, D.C. Florian
Format: Article
Language:English
Subjects:
Absorbable Implants
alloys
Animals
Apatite
Biodegradability
Biodegradable magnesium implants
Biodegradation
Biomaterials Science
Biomaterialvetenskap
Blood Platelets - drug effects
Bone and Bones - ultrastructure
Bone implants
Bone matrix
Bone ultrastructure
Bone-implant
Bone-implant interface
Crystallites
Crystallization
Crystals
Degradation
Dentistry
Durapatite - pharmacology
Engineering
Gadolinium
Gadolinium - pharmacology
Hydroxyapatite
in-vitro
interface
Lattice theory
Magnesium
Magnesium - pharmacology
Magnesium base alloys
Male
Materials Science
Mechanical properties
Metals
Mineralization
nanostructure
Odontologi
Protective coatings
Rats, Sprague-Dawley
Small angle X ray scattering
Statistical analysis
Surgical implants
Titanium
Titanium - pharmacology
Transplants & implants
Ultrastructure
X-Ray Diffraction
X-ray scattering
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Summary:Magnesium alloys are increasingly researched as temporary biodegradable metal implants in bone applications due to their mechanical properties which are more similar to bone than conventional implant metals and the fact that Magnesium occurs naturally within the body. However, the degradation processes in vivo and in particular the interaction of the bone with the degrading material need to be further investigated. In this study we are presenting the first quantitative comparison of the bone ultrastructure formed at the interface of biodegradable Mg–5Gd and Mg–10Gd implants and titanium and PEEK implants after 4, 8 and 12 weeks healing time using two-dimensional small angle X-ray scattering and X-ray diffraction. Differences in mineralization, orientation and thickness of the hydroxyapatite are assessed. We find statistically significant (p 
ISSN:1742-7061
1878-7568
1878-7568
DOI:10.1016/j.actbio.2019.11.030