Prenylated Flavonoids from the Roots of Tephrosia rhodesica

Five new compoundsrhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometri...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2020-08, Vol.83 (8), p.2390-2398
Main Authors: Atilaw, Yoseph, Muiva-Mutisya, Lois, Bogaerts, Jonathan, Duffy, Sandra, Valkonen, Arto, Heydenreich, Matthias, Avery, Vicky M, Rissanen, Kari, Erdélyi, Máté, Yenesew, Abiy
Format: Article
Language:English
Subjects:
heartwood
maackiain
Molecular Biology
Molekylärbiologi
Pharmacology & Pharmacy
Plant Sciences
pterocarpan
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Summary:Five new compoundsrhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)along with 16 known secondary metabolites, were isolated from the CH2Cl2–CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2–5, 9, 15, and 21 showed activity (100% at 10 μg and IC50 = 5–15 μM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.0c00245