Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

Maternal diet can influence the developing immune system of the offspring. We hypothesized that maternal fibre and gluten intake during pregnancy were associated with the risk of celiac disease in the child. In the Norwegian Mother, Father and Child Cohort Study (MoBa, n = 85,898) higher maternal fi...

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Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.16439, Article 16439
Main Authors: Lund-Blix, Nicolai A., Tapia, German, Mårild, Karl, Brantsæter, Anne Lise, Eggesbø, Merete, Mandal, Siddhartha, Stene, Lars C., Størdal, Ketil
Format: Article
Language:English
Subjects:
692/308/3187
692/4020/1503/1581/1357
Adult
Autoimmune diseases
Celiac disease
Celiac Disease - etiology
Childhood
Children
cohort
consumption
Diet
Dietary Fiber - administration & dosage
Fatty acids
Fecal microflora
Female
frequency
Gluten
Glutens - administration & dosage
Humanities and Social Sciences
Humans
Immune system
infections
Microbiomes
microbiota
multidisciplinary
Norway
norwegian mother
Nutrition and Dietetics
Näringslära
Offspring
Pediatrics
Pediatrik
Pregnancy
Prenatal Exposure Delayed Effects - etiology
prevalence
Prospective Studies
Risk Factors
Science
Science & Technology - Other Topics
Science (multidisciplinary)
wheat
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Summary:Maternal diet can influence the developing immune system of the offspring. We hypothesized that maternal fibre and gluten intake during pregnancy were associated with the risk of celiac disease in the child. In the Norwegian Mother, Father and Child Cohort Study (MoBa, n = 85,898) higher maternal fibre intake (median 29.5 g/day) was associated with a lower risk of celiac disease in the offspring (adjusted relative risk 0.90, 95% CI 0.83 to 0.98 per 10 g/d increase). Gluten intake during pregnancy (median 13.0 g/d) was associated with a higher risk of childhood CD (adjusted relative risk = 1.21, 95% CI 1.02 to 1.43 per 10 g/d increase). These results were largely unaffected by adjustment for the child’s gluten intake at 18 months. In an independent study of 149 mother/child dyads, maternal fibre intake did not predict concentrations of total or sub-types of short-chain fatty acids in repeated infant stool samples, or fecal microbiome diversity in the mother or child. Our results suggest that high fibre and low gluten intake during pregnancy could be protective factors for celiac disease, although the mechanism is unknown.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-73244-4