Effect of Obstructive Sleep Apnea and CPAP Treatment on Cardiovascular Outcomes in Acute Coronary Syndrome in the RICCADSA Trial

We aimed to address the impact of OSA and its treatment with continuous positive airway pressure (CPAP) on major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome (ACS). In this current analysis of the revascularized ACS subgroup ( = 353) of the Rando...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2020-12, Vol.9 (12), p.4051
Main Authors: Peker, Yüksel, Thunström, Erik, Glantz, Helena, Eulenburg, Christine
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Cardiovascular disease
Clinical Medicine
Continuous positive airway pressure
Coronary vessels
Diabetes
Heart attacks
Intervention
Klinisk medicin
Mortality
Patients
R&D
Research & development
Sleep apnea
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to address the impact of OSA and its treatment with continuous positive airway pressure (CPAP) on major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute coronary syndrome (ACS). In this current analysis of the revascularized ACS subgroup ( = 353) of the Randomized Intervention with CPAP in Coronary Artery Disease and Obstructive Sleep Apnea (RICCADSA) trial (Trial Registry: ClinicalTrials.gov; No: NCT00519597), participants with non-sleepy OSA (apnea-hypopnea-index [AHI] ≥ 15 events/h on a home sleep apnea testing, and Epworth Sleepiness Scale [ESS] score < 10; = 171) were randomized to CPAP ( = 86) or no-CPAP ( = 85). The sleepy OSA patients (AHI ≥ 15 events/h and ESS ≥ 10) who were offered CPAP, and the ones with no-OSA (AHI < 5 events/h) were included in the observational arm. A post-hoc analysis was done to compare untreated OSA (no-CPAP; = 78) and nonadherent sleepy/non-sleepy OSA ( = 96) with the reference group without OSA ( = 81). The primary endpoint (the first event of repeat revascularization, myocardial infarction, stroke or cardiovascular mortality) during a median 4.7-year follow-up was evaluated in time-dependent Cox proportional hazards models adjusted for confounding factors. The incidence of MACCE did not differ significantly in intention-to-treat population. On-treatment analysis showed a significant risk reduction in those who used CPAP for ≥4 vs.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9124051