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Prehospital lactate levels in blood as a seizure biomarker: A multi‐center observational study

Objective The objective of this study was to assess the value of prehospital measurement of lactate level in blood for diagnosis of seizures in cases of transient loss of consciousness. Methods Between March 2018 and September 2019, prehospital lactate was measured with a point‐of‐care device by the...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2021-02, Vol.62 (2), p.408-415
Main Authors: Magnusson, Carl, Herlitz, Johan, Höglind, Robert, Wennberg, Pär, Edelvik Tranberg, Anna, Axelsson, Christer, Zelano, Johan
Format: Article
Language:English
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Summary:Objective The objective of this study was to assess the value of prehospital measurement of lactate level in blood for diagnosis of seizures in cases of transient loss of consciousness. Methods Between March 2018 and September 2019, prehospital lactate was measured with a point‐of‐care device by the emergency medical services in an area serving a population of 900 000. A total of 383 cases of transient loss of consciousness were identified and categorized as tonic‐clonic seizure (TCS), other seizure, syncope, or other cause, according to the final diagnosis in the electronic medical records system. Receiver operating characteristic curve analyses were used to identify the optimal lactate cut‐off. Results A total of 383 cases were included (135 TCS, 42 other seizure, 163 syncope, and 43 other causes). The median lactate level in TCS was 7.0 mmol/L, compared to a median of 2.0 mmol/L in all other cases (P 
ISSN:0013-9580
1528-1167
1528-1167
DOI:10.1111/epi.16806