Mucosal Immune Responses Against an Oral Enterotoxigenic Escherichia coli Vaccine Evaluated in Clinical Trials

Abstract Enterotoxigenic Escherichia coli (ETEC) is a leading cause of mortality and morbidity in children in low-income countries. We have tested an oral ETEC vaccine, ETVAX, consisting of inactivated E coli overexpressing the most prevalent colonization factors and a toxoid, LCTBA, administered to...

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Bibliographic Details
Published in:The Journal of infectious diseases 2021-12, Vol.224 (Supplement_7), p.S821-S828
Main Authors: Svennerholm, Ann-Mari, Lundgren, Anna, Leach, Susannah, Akhtar, Marjahan, Qadri, Firdausi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Bacterial
Antigens
Child
Clinical trials
Colonization
double-blind
E coli
Enteric Diseases and Nutritional Disorders: Persisting Challenges for LMICs
Enterotoxigenic Escherichia coli - immunology
Enterotoxins
Escherichia coli
Escherichia coli Infections - prevention & control
Escherichia coli Proteins
Escherichia coli Vaccines - administration & dosage
ETEC
Humans
Immune response
Immunity, Mucosal
immunogenicity
Immunological memory
Immunology
Infant
Infectious Diseases
Infectious Medicine
Infektionsmedicin
Intestine
Microbiology
Middle Aged
Morbidity
mucosal immune responses
Mucosal immunity
O antigen
safety
vaccine
Vaccines
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Summary:Abstract Enterotoxigenic Escherichia coli (ETEC) is a leading cause of mortality and morbidity in children in low-income countries. We have tested an oral ETEC vaccine, ETVAX, consisting of inactivated E coli overexpressing the most prevalent colonization factors and a toxoid, LCTBA, administered together with a mucosal adjuvant, double-mutant heat-labile toxin (dmLT), for capacity to induce mucosal immune responses and immunological memory against the primary vaccine antigens, ie, colonization factors, heat-labile toxin B-subunit and O antigen. The studies show that ETVAX could induce strong intestine-derived and/or fecal immune responses in a majority of vaccinated Swedish adults and in different age groups, including infants, in Bangladesh.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiab475