Protein tau concentration in blood increases after SCUBA diving: an observational study

Purpose It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving. Methods Thirty-two divers performed two identical dives, 48 h apart, in a water-filled hyperbaric ch...

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Bibliographic Details
Published in:European journal of applied physiology 2022-04, Vol.122 (4), p.993-1005
Main Authors: Rosén, Anders, Gennser, Mikael, Oscarsson, Nicklas, Kvarnström, Andreas, Sandström, Göran, Seeman-Lodding, Helen, Simrén, Joel, Zetterberg, Henrik
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Armed forces
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood levels
Brain
Brain research
bubble formation
Central nervous system
decompression
Diving
Diving research
Doppler effect
Fysiologi
Gases
Glial fibrillary acidic protein
Human Physiology
Idrottsvetenskap
injury
Intensive care
Nervous system
Neurochemistry
Neuronal-glial interactions
Neuropsychology
Neurosciences
Neurovetenskaper
Nitrogen
Observational studies
Occupational Medicine/Industrial Medicine
Original
Original Article
oxidative stress
oxygen
Physiology
professional divers
Proteins
Recreation
serum tau
Sport and Fitness Sciences
Sport Sciences
Sports Medicine
Tau protein
Ultrasonic imaging
Venous gas embolism
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Summary:Purpose It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving. Methods Thirty-two divers performed two identical dives, 48 h apart, in a water-filled hyperbaric chamber pressurized to an equivalent of 42 m of sea water for 10 min. After one of the two dives, normobaric oxygen was breathed for 30 min, with air breathed after the other. Blood samples were obtained before and at 30–45 and 120 min after diving. Concentrations of glial fibrillary acidic, neurofilament light, and tau proteins were measured using single molecule array technology. Doppler ultrasound was used to detect venous gas emboli. Results Tau was significantly increased at 30–45 min after the second dive ( p  
ISSN:1439-6319
1439-6327
1439-6327
DOI:10.1007/s00421-022-04892-9