Forty-four-year longitudinal study of stroke incidence and risk factors - the Prospective Population Study of Women in Gothenburg

• Published in: Scandinavian journal of primary health care 2022-03, Vol.40 (1), p.139-147
• Main Authors: Blomstrand, Ann, Blomstrand, Christian, Hakeberg, Magnus, Sundh, Valter, Lissner, Lauren, Björkelund, Cecilia
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Allmän medicin; Associations; Atrial fibrillation; Atrial Fibrillation - epidemiology; Blood pressure; Bone mineral density; Cardiac arrhythmia; Cholesterol; Clinical Medicine; determinants; Diabetes; Diabetes Mellitus - epidemiology; disease; Eclampsia; education; Exercise; Family Medicine; Female; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; follow-up; General & Internal Medicine; health; Health care; Health Care Sciences & Services; Humans; Hypertension; Hypertension - complications; Hypertension - epidemiology; Incidence; Klinisk medicin; Longitudinal Studies; men; Middle Aged; Myocardial infarction; Neurologi; Neurology; Oral health; Oral hygiene; Original; Physical activity; Pre-Eclampsia; Preeclampsia; Pregnancy; Prevention; Preventive medicine; Primary care; Prospective Studies; Public Health, Global Health, Social Medicine and Epidemiology; Risk Factors; sex-differences; Smoking; socioeconomic-status; Stroke; Stroke - epidemiology; Teeth; temporal trends; tooth loss; Triglycerides; Vulnerability; Women
• ISSN: 0281-3432; 1502-7724; 1502-7724
• DOI: 10.1080/02813432.2022.2057040

To assess stroke incidence over 44 years and association with risk factors. To study total stroke incidence at 60-82 years of age and risk factors. Prospective population study. Gothenburg, Sweden, with ∼450,000 inhabitants. A representative sample of a general population of women (1462 in total) in 5 age strata aged 38-60 years in 1968-1969 (the Population Study of Women in Gothenburg, PSWG) were followed up to the ages of 82-104 years in 2012. Further, analysis was also performed for the age interval 60-82 years. Incidence of total stroke (TS), ischaemic (IS), haemorrhagic (HS), non-specified (NS) and fatal (FS) strokes and association with baseline classic risk factors (such as hypertension, atrial fibrillation, low physical activity, diabetes, high waist-hip-ratio, hyperlipidaemia, smoking), low education, mental stress, pre-eclampsia and oral health as expressed by loss of teeth and bone score. Blood pressure in levels 1-3 according to modern guidelines. Associations with atrial fibrillation, diabetes and myocardial infarction shown in survival analyses. The five cohorts contributed to risk time data concerning associations with TS in the 60-82 age interval from the examination performed when they were 60. Three hundred and thirty-seven (23%) women had a first-ever stroke, 64 (19%) fatal. TS was associated with physical inactivity, high triglycerides and low education in multivariable analysis. The main sub-type IS was associated with systolic blood pressure, physical inactivity and low education. Pre-eclampsia showed association with IS only in the univariable analysis. FS was associated with systolic blood pressure and smoking. During 60-82 years of age, having