Incidence of congenital malformations in children born after ICSI

The aim of this study was to determine the incidence of congenital malformations in a complete cohort of children born after intracytoplasmic sperm injection (ICSI). The medical records were retrieved for 1139 infants, 736 singletons, 200 sets of twins and one set of triplets. The total number of in...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 2000-04, Vol.15 (4), p.944-948
Main Authors: Wennerholm, U.-B., Bergh, C., Hamberger, L., Lundin, K., Nilsson, L., Wikland, M., Källén, B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth control
Chromosome Aberrations
Cohort Studies
Congenital Abnormalities - epidemiology
Female
Gynecology. Andrology. Obstetrics
Humans
Hydrocephalus - epidemiology
Hypospadias - epidemiology
Infant, Newborn
Infertility, Male - therapy
intracytoplasmic sperm injection
Male
malformations
Medical sciences
Neural Tube Defects - epidemiology
Obstetrics, Gynecology and Reproductive Medicine
Pregnancy
Pregnancy, Multiple
Prenatal Diagnosis
Reproduktionsmedicin och gynekologi
Sperm Injections, Intracytoplasmic
Sterility. Assisted procreation
Sweden - epidemiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to determine the incidence of congenital malformations in a complete cohort of children born after intracytoplasmic sperm injection (ICSI). The medical records were retrieved for 1139 infants, 736 singletons, 200 sets of twins and one set of triplets. The total number of infants with an identified anomaly was 87 (7.6%), 40 of which were minor. The incidence of malformations in children born after ICSI was also compared with all births in Sweden using data from the Swedish Medical Birth Registry and the Registry of Congenital Malformations. For ICSI children, the odds ratio (OR) for having any major or minor malformation was 1.75 [95% confidence interval (CI) 1.19–2.58] after stratification for delivery hospital, year of birth and maternal age. If stratification for singletons/twins was also done, the OR was reduced to 1.19 (95% CI 0.79–1.81). The increased rate of congenital malformations is thus mainly a result of a high rate of multiple births. The only specific malformation which was found to occur in excess in children born after ICSI was hypospadias (relative risk 3.0, exact 95% CI 1.09–6.50) which may be related to paternal subfertility.
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/15.4.944