Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology

Abstract Despite viral suppression with antiretroviral therapy (ART), people with human immunodeficiency virus (HIV) continue to experience central nervous system (CNS) complications, primarily in the form of mild cognitive impairment and mental health disorders (eg, depression, anxiety, other neuro...

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Bibliographic Details
Published in:The Journal of infectious diseases 2023-03, Vol.227 (Supplement_1), p.S3-S15
Main Authors: Joseph, Sarah B, Gianella, Sara, Burdo, Tricia H, Cinque, Paola, Gisslen, Magnus, Letendre, Scott, Nath, Avindra, Morgello, Susan, Ndhlovu, Lishomwa C, Spudich, Serena
Format: Article
Language:English
Subjects:
Antiretroviral therapy
biomarkers
biotype
Biotypes
Biotyping
ccr5 utilization
Central Nervous System
Central Nervous System Diseases - etiology
cerebrospinal-fluid
CNS Complications Supplement
Cognitive ability
Cognitive Dysfunction
HAND
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV-1
HIV-associated cognitive disorder
hiv-infection
Human immunodeficiency virus
Humans
Immunology
Infectious Diseases
Infectious Medicine
Infektionsmedicin
inflammation
lymphoid-tissues
macrophage tropism
Mental disorders
Microbiology
neurocognitive disorders
neurofilament protein nfl
neuroHIV
perivascular macrophages
Phenotypes
treatment intensification
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Summary:Abstract Despite viral suppression with antiretroviral therapy (ART), people with human immunodeficiency virus (HIV) continue to experience central nervous system (CNS) complications, primarily in the form of mild cognitive impairment and mental health disorders (eg, depression, anxiety, other neuropsychiatric problems). The multifactorial pathogenesis and heterogeneity of mechanisms likely underlying CNS complications must be addressed in the development of preventive interventions and effective treatments. The biotyping approach has previously been useful to define phenotypes of other CNS diseases based on underlying mechanisms and could be translated to the field of neuroHIV. The purpose of the Biotype Workshop series, and the Virology, Immunology and Neuropathology Working Group in particular, is to capitalize on current and new technologies and guide future research efforts using the wealth of available immunological, virologic, and neuropathological data collected from people with HIV on and off ART.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiac370