Moving Beyond Depression: Mood Symptoms Across the Spectrum Relate to Tau Pathology in Older Women at Risk for Alzheimer's Disease

We examined how symptoms across the mood spectrum relate to Alzheimer's disease (AD) biomarkers in older women at high risk for AD. Participants included 25 women aged 65+ with mild cognitive deficits and elevated AD genetic risk. The Profile of Mood States Questionnaire measured mood symptoms...

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Bibliographic Details
Published in:International journal of aging & human development 2025-01, Vol.100 (1), p.3-22
Main Authors: Ahmadi, Nargis, Dratva, Melanie A, Heyworth, Nadine, Wang, Xin, Blennow, Kaj, Banks, Sarah J., Sudermann, Erin E.
Format: Article
Language:English
Subjects:
Affect - physiology
Aged
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - psychology
Alzheimer's disease
Amyloid beta-Peptides - blood
Amyloid beta-Peptides - metabolism
Biomarkers - blood
Cognitive Dysfunction - blood
Cognitive Dysfunction - psychology
dementia
Depression - blood
Depression - metabolism
Depression - psychology
Emotions
Female
Genetics
Health risk assessment
Humans
Mental depression
mood symptoms
Older people
Pathology
Positron-Emission Tomography
Psychiatry
Psykiatri
Risk
Symptoms
tau pathology
tau Proteins - blood
tau Proteins - metabolism
Well being
Women
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Summary:We examined how symptoms across the mood spectrum relate to Alzheimer's disease (AD) biomarkers in older women at high risk for AD. Participants included 25 women aged 65+ with mild cognitive deficits and elevated AD genetic risk. The Profile of Mood States Questionnaire measured mood symptoms and a total mood disturbance (TMD) score. Tau burden in the meta-temporal region of interest was measured using MK-6240 Tau positron emission tomography (PET) imaging. A subset (n = 12) also had p-Tau181, and Aß40/42 levels measured in plasma. Higher TMD scores related to higher tau PET standardized uptake value ratio (SUVR). Greater negative mood symptoms correlated with higher tau PET SUVR, while greater vigor correlated with lower SUVR. Similar results were seen with plasma p-Tau181 levels, but not with Aβ40/42 levels. In conclusion, positive and negative mood symptoms related to tau pathology in older women at high risk for AD, highlighting a role of mental well-being in AD risk.
ISSN:0091-4150
1541-3535
1541-3535
DOI:10.1177/00914150241253257