Effects of heavy‐load strength training during (neo‐)adjuvant chemotherapy on muscle strength, muscle fiber size, myonuclei, and satellite cells in women with breast cancer

• Published in: The FASEB journal 2024-07, Vol.38 (13), p.e23784-n/a
• Main Authors: Vikmoen, Olav, Strandberg, Emelie, Svindland, Karianne Vassbakk, Henriksson, Anna, Mazzoni, Anne‐Sophie, Johansson, Birgitta, Jönsson, Janniz, Karakatsanis, Andreas, Annebäck, Matilda, Kudrén, David, Lindman, Henrik, Wärnberg, Fredrik, Berntsen, Sveinung, Demmelmaier, Ingrid, Nordin, Karin, Raastad, Truls
• Format: Article
• Language: English
• Subjects: Adult; Aged; Body Composition; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer and Oncology; Cancer och onkologi; Chemotherapy, Adjuvant; drug therapy; exercise; Female; Humans; Middle Aged; muscle cells; Muscle Fibers, Skeletal - drug effects; Muscle Fibers, Skeletal - pathology; Muscle Fibers, Skeletal - physiology; Muscle Strength; Neoadjuvant Therapy; resistance training; Resistance Training - methods; Satellite Cells, Skeletal Muscle - drug effects
• ISSN: 0892-6638; 1530-6860; 1530-6860
• DOI: 10.1096/fj.202400634R

To investigate the effects of heavy‐load strength training during (neo‐)adjuvant chemotherapy in women with breast cancer on muscle strength, body composition, muscle fiber size, satellite cells, and myonuclei. Women with stage I‐III breast cancer were randomly assigned to a strength training group (ST, n = 23) performing supervised heavy‐load strength training twice a week during chemotherapy, or a usual care control group (CON, n = 17). Muscle strength and body composition were measured and biopsies from m. vastus lateralis collected before the first cycle of chemotherapy (T0) and after chemotherapy and training (T1). Muscle strength increased significantly more in ST than in CON in chest‐press (ST: +10 ± 8%, p