Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men

The apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death. The aim was to examine whether apoB/apoA-I was associated with the metabolic syndrome (MetS) at baseline and also with th...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2004-10, Vol.35 (10), p.2248-2252
Main Authors: WALLENFELDT, Karin, BOKEMARK, Lena, WIKSTRAND, John, HULTHE, Johannes, FAGERBERG, Björn
Format: Article
Language:English
Subjects:
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Arteriosclerosis - blood
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Body Mass Index
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Carotid Arteries/pathology/ultrasonography
Humans
Lipoproteins - blood
Male
MEDICAL AND HEALTH SCIENCES
Medical sciences
MEDICIN OCH HÄLSOVETENSKAP
Metabolic Syndrome - blood
Metabolic Syndrome X/blood
Middle Aged
Neurology
Neurosurgery
Obesity - blood
Skull, brain, vascular surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tunica Intima - diagnostic imaging
Tunica Intima - pathology
Tunica Intima/pathology/ultrasonography
Ultrasonography
Vascular diseases and vascular malformations of the nervous system
Waist-Hip Ratio
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death. The aim was to examine whether apoB/apoA-I was associated with the metabolic syndrome (MetS) at baseline and also with the future change in carotid artery intima-media thickness (IMT). In 313 58-year-old men, carotid artery IMT was measured bilaterally by high-resolution B-mode ultrasound at baseline and after 3 years of follow-up. Serum apolipoprotein concentrations and the components of MetS were measured at study entry. ApoB/apoA-I showed statistically significant associations with body mass index, waist-to-hip ratio, high-density lipoprotein (HDL) cholesterol, triglycerides, low-density lipoprotein (LDL) particle size, insulin, and diastolic blood pressure. Two thirds of the patients with MetS had high apoB/apoA-I ratios (>0.90) compared with one third of those without the syndrome (P
ISSN:0039-2499
1524-4628
1524-4628
DOI:10.1161/01.str.0000140629.65145.3c