Hemodynamic improvement and removal of autoantibodies against beta1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy

The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoan...

Full description

Saved in:
Bibliographic Details
Published in:Journal of autoimmunity 2003-06, Vol.20 (4), p.345-350
Main Authors: Mobini, Reza, Staudt, Alexander, Felix, Stephan B, Baumann, Gert, Wallukat, Gert, Deinum, Johanna, Svensson, Helen, Hjalmarson, Ake, Fu, Michael
Format: Article
Language:English
Subjects:
Adrenergic
Autoantibodies
Autoantibodies - blood
Autoantibodies - isolation & purification
beta-1
blood
Cardiomyopathy
Cardiomyopathy, Dilated - immunology
Cardiomyopathy, Dilated - physiopathology
Cardiomyopathy, Dilated - therapy
Case-Control Studies
Cell and Molecular Biology
Cell- och molekylärbiologi
Dilated
Fysiologi
Hemodynamic Processes
Hemodynamics
Humans
immunology
Immunosorbent Techniques
Immunotherapy
isolation & purification
Left
Male
Microbiology in the medical area
Middle Aged
Mikrobiologi inom det medicinska området
Physiology
physiopathology
Receptors
Receptors, Adrenergic, beta-1 - immunology
therapy
Ventricular Function
Ventricular Function, Left
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against the human beta(1)AR with the hemodynamic improvement induced by IA was investigated.IA was performed in 22 DCM patients (n=22; NYHA III-IV, EF
ISSN:0896-8411