On the site and mechanism of action of the anti-obesity effects of interleukin-6

We conducted an experimental study examining the site and mechanism of action of the anti-obesity effect of interleukin-6 (IL-6) in mice and rats. We used dual energy X-ray absorptiometry (DEXA) and computerized tomography to investigate the body composition of mice with knockout of the IL-6 gene an...

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Bibliographic Details
Published in:Growth hormone & IGF research 2003-08, Vol.13, p.S28-S32
Main Authors: Jansson, John-Olov, Wallenius, Kristina, Wernstedt, Ingrid, Ohlsson, Claes, Dickson, Suzanne L, Wallenius, Ville
Format: Article
Language:English
Subjects:
Adipose Tissue
Adipose Tissue - drug effects
Animals
Anti-Obesity Agents
Anti-Obesity Agents - pharmacology
Blood Glucose
Blood Glucose - metabolism
Body Weight
Body Weight - drug effects
Brain
Brain - drug effects
drug effects
drug therapy
Energy Metabolism
Energy Metabolism - drug effects
Injections
Injections, Intraventricular
Interleukin-6
Interleukin-6 - pharmacology
Interleukin-6 - physiology
Intraventricular
Knockout
MEDICAL AND HEALTH SCIENCES
MEDICIN OCH HÄLSOVETENSKAP
metabolism
Mice
Mice, Knockout
Obesity
Obesity - drug therapy
Obesity - metabolism
Oxygen Consumption
Oxygen Consumption - drug effects
pharmacology
physiology
Rats
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Summary:We conducted an experimental study examining the site and mechanism of action of the anti-obesity effect of interleukin-6 (IL-6) in mice and rats. We used dual energy X-ray absorptiometry (DEXA) and computerized tomography to investigate the body composition of mice with knockout of the IL-6 gene and wild-type control mice. Rats were treated with IL-6 or vehicle through intracerebroventricular (ICV) cannulae. Energy expenditure was measured as oxygen consumption by indirect calorimetry in metabolic chambers. Results showed that the mice lacking IL-6 increased in body weight compared with wild-type mice from 6 months of age onward, although there was no marked difference in food intake between the pre-obese IL-6 knockout mice and the wild-type mice. IL-6 given as a single ICV injection to rats stimulated oxygen consumption; whereas, the same doses were ineffective when given peripherally. Chronic ICV IL-6 treatment decreased body weight and fat mass in rodents. Administration of IL-6 may decrease fat mass in mice and rats by stimulating energy expenditure at the CNS level, possibly in the hypothalamus.
ISSN:1096-6374
1532-2238
DOI:10.1016/S1096-6374(03)00051-0