Survival and erythropoietin receptor protein in tumours from patients randomly treated with rhEPO for palliative care

• Published in: Medical oncology (Northwood, London, England) London, England), 2008-03, Vol.25 (1), p.22-29
• Main Authors: Lönnroth, Christina, Svensson, Marie, Wang, Wenhua, Körner, Ulla, Daneryd, Peter, Nilsson, Ola, Lundholm, Kent
• Format: Article
• Language: English
• Subjects: analysis; Anemia; Anemia - drug therapy; Anemia - etiology; chemistry; complications; drug therapy; Erythropoietin; Erythropoietin - therapeutic use; etiology; Female; Hematology; Humans; Internal Medicine; Ki-67 Antigen; Ki-67 Antigen - analysis; Male; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Medicine; Medicine & Public Health; mortality; Neoplasms; Neoplasms - chemistry; Neoplasms - complications; Neoplasms - mortality; Neoplasms - pathology; Oncology; Original Paper; Palliative Care; Pathology; Receptors; Receptors, Erythropoietin - analysis; Recombinant; Recombinant Proteins; therapeutic use
• ISSN: 1357-0560; 1559-131X
• DOI: 10.1007/s12032-007-9001-7

Background Recombinant erythropoietin (rhEPOα) corrects anaemia, improves physical functioning and quality of life in cancer patients. However, published reports have suggested risks for tumour stimulation by provision EPO to patients with remaining tumour cells perhaps related to the presence of EPO receptor protein in tumour tissue. Therefore, the aim of the present study was to exclude a possibility that cancer patients who respond favourably to EPO treatment have mainly tumours with low EPO receptor protein expression. Methods Tumour tissue was evaluated in 87 patients out of 108 randomly allocated for treatment with rhEPOα ( n  = 50) versus controls ( n  = 58). Tumour cell proliferation (Ki-67 index) and EPO receptor protein expression were evaluated by immunohistochemistry. Results EPO treatment varied between 2 and 35 months, in doses between 10 000 and 40 000 Units/week. Ki-67 index did not differ between study and control patients before EPO treatment. Tumour tissue erythropoietin receptor protein was also similar between treated and untreated patients. Around 40% of tumour cells contained EPO receptors. Survival did not differ among EPO treated and control patients analysed as intention to treat, while survival was significantly improved in EPO treated patients per protocol treatment ( P