Uterine transplantation

Uterine factor infertility is either due to congenital malformation or acquired. Most women with uterine factor infertility have no chance to become genetic mothers, except by the use of gestational surrogacy. The logical but radical approach for treatment would be replacement of the unfunctional or...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2003-08, Vol.109 (2), p.121-123
Main Authors: Brännström, Mats, El-Akouri, Randa Racho, Wranning, Caiza Almén
Format: Article
Language:English
Subjects:
Adult
Animal
Animals
Biological and medical sciences
blood supply
Female
Graft Rejection
Gynaecology, Obstetrics and Reproductive Medicine
Gynekologi, obstetrik och reproduktionsmedicin
Humans
Immunosuppression
Infertility
Infertility, Female - surgery
Kirurgi
Medical sciences
Mice
Pregnancy
Pregnancy Outcome
Pregnancy, Animal
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Transplantation
Transplantation Immunology
Uterine factor
Uterus
Uterus - blood supply
Uterus - transplantation
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Summary:Uterine factor infertility is either due to congenital malformation or acquired. Most women with uterine factor infertility have no chance to become genetic mothers, except by the use of gestational surrogacy. The logical but radical approach for treatment would be replacement of the unfunctional or absent uterus. Uterine transplantation could allow these women to become both genetic and gestational mothers. The present work reviews the existing literature on the history and recent development around this topic. We also briefly describe a newly developed model for heterotopic uterine transplantation in the mouse, in which pregnancies have been accomplished. Some specific issues that are required to be solved prior any further attempts to transplant the uterus in humans are also addressed.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(03)00050-2