Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress

Background:Particulate air pollution affects cardiovascular and pulmonary disease and mortality. A main hypothesis about the mechanisms involved is that particles induce inflammation in lower airways, systemic inflammation and oxidative stress.Objectives:To examine whether short-term exposure to woo...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2008-05, Vol.65 (5), p.319-324
Main Authors: Barregard, L, Sällsten, G, Andersson, L, Almstrand, A-C, Gustafson, P, Andersson, M, Olin, A-C
Format: Article
Language:English
Subjects:
Adult
adverse effects
Air
Air cleanliness
Air pollution
analysis
Biological and medical sciences
Biological Markers
Biomarkers
Biomarkers - metabolism
Breath tests
Bronchitis
Bronchitis - chemically induced
Bronchitis - physiopathology
Chemical hazards
chemically induced
Diesel exhaust
Environmental pollutants toxicology
Exposure
Female
Humans
Hydrocarbons
Hypotheses
Indoor environments
Inhalation Exposure
Inhalation Exposure - adverse effects
Lung
Lung - metabolism
Lung - physiopathology
Lungmedicin och allergi
Male
Medical sciences
metabolism
Middle Aged
Nitric Oxide
Nitric Oxide - metabolism
Outdoor air quality
Oxidative Stress
Oxides
Particle Size
Particulate matter
physiopathology
Proteins
Pulmonary alveoli
Respiratory Medicine and Allergy
Respiratory tract
Smoke
Smoke - adverse effects
Smoke - analysis
Toxicology
Urine
Uteroglobin
Uteroglobin - metabolism
Wood
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Summary:Background:Particulate air pollution affects cardiovascular and pulmonary disease and mortality. A main hypothesis about the mechanisms involved is that particles induce inflammation in lower airways, systemic inflammation and oxidative stress.Objectives:To examine whether short-term exposure to wood smoke in healthy subjects affects markers of pulmonary inflammation and oxidative stress.Methods:13 subjects were exposed first to clean air and then to wood smoke in a chamber during 4-hour sessions, 1 week apart. The mass concentrations of fine particles at wood smoke exposure were 240–280 μg/m3, and number concentrations were 95 000–180 000/cm3, about half of the particles being ultrafine (
ISSN:1351-0711
1470-7926
1470-7926
DOI:10.1136/oem.2006.032458