Localised astroglial dysfunction disrupts high-frequency EEG rhythms

We used cerebral cortex injections of fluorocitrate to determine if selective astrocytic disturbances affect the electroencephalogram (EEG). Rats were halothane-anaesthetized and 0.8 nmol of sodium fluorocitrate was injected into hindlimb (motor-sensory) cortex. Extra-dural EEG electrodes were impla...

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Bibliographic Details
Published in:JOURNAL OF NEURAL TRANSMISSION 2005-02, Vol.112 (2), p.205-213
Main Authors: Willoughby, J O, Mackenzie, L, Pope, K J, Broberg, M, Nilsson, M
Format: Article
Language:English
Subjects:
Animals
astrocytes
Astrocytes - drug effects
Astrocytes - physiology
cellular-level
Citrates - administration & dosage
Electroencephalography - drug effects
Electroencephalography - methods
gamma eeg
Gap Junctions - drug effects
Gap Junctions - physiology
glia
in-vivo
Male
Motor Cortex - drug effects
Motor Cortex - physiology
Neurologi
Neurology
neurons
Neurosciences
Neurovetenskaper
rat-brain
Rats
Rats, Wistar
synaptic-transmission
tasks
volume
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Summary:We used cerebral cortex injections of fluorocitrate to determine if selective astrocytic disturbances affect the electroencephalogram (EEG). Rats were halothane-anaesthetized and 0.8 nmol of sodium fluorocitrate was injected into hindlimb (motor-sensory) cortex. Extra-dural EEG electrodes were implanted after which the anaesthesia was ceased. EEG was recorded at 1, 3, 5, 7, 24 and 48 hours. There was a broad-band reduction in frequencies in the EEG between 20 and 100 Hz commencing within 1 hour of injection and largely restricted to the side of injection and to frontal cortex, and maximal at 3 hours. Halothane had a suppressive effect on gamma power after citrate injection, but also prevented EEG suppression caused by fluorocitrate, consistent with the hypothesis that some of the action of fluorocitrate depended on gap-junctions. The findings are consistent with the hypothesis that primary astroglial dysfunction leads to reduced neuronal transmission and further supports gap-junctions as mediating fluorocitrate-induced astroglial effects.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-004-0189-9