Renal function in predialysis children with chronic renal failure treated with erythropoietin

To assess the effect of long-term administration of human recombinant erythropoietin (EPO) on renal function, 11 anemic children aged 1.4-17.2 years were followed for 10-61 (mean 31) months on treatment. During EPO therapy the mean hemoglobin rose from 8.1 to 11.1 g/dl at the last observation. The f...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1997-02, Vol.11 (1), p.69-73
Main Authors: KRMAR, R. T, GRETZ, N, KLARE, B, WÜHL, E, SCHÄRER, K
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Blood Pressure - physiology
Child
Child, Preschool
Creatinine - blood
Erythropoietin - adverse effects
Erythropoietin - therapeutic use
Female
Hemoglobins - metabolism
Humans
Infant
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - physiopathology
Kidney Function Tests
Male
Medical sciences
Medicin och hälsovetenskap
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Recombinant Proteins
Renal Dialysis
Renal failure
Retrospective Studies
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Summary:To assess the effect of long-term administration of human recombinant erythropoietin (EPO) on renal function, 11 anemic children aged 1.4-17.2 years were followed for 10-61 (mean 31) months on treatment. During EPO therapy the mean hemoglobin rose from 8.1 to 11.1 g/dl at the last observation. The final maintenance dose ranged between 70 and 300 U/kg per week. The rate of deterioration of renal function was calculated by comparing the slope of the regression lines of reciprocal serum creatinine values (SCr) derived from a mean of 20 values per patient obtained over 8-50 (mean 29) months before and a mean of 24 SCR values during EPO therapy. The individual slopes improved after initiation of EPO therapy in all but 3 patients, but the mean change of slope (from -0.0521 to -0.0299) was not significant. The study suggests that in most children with predialysis chronic renal failure long-term administration of EPO is not associated with accelerated deterioration but rather with delayed deterioration of renal function.
ISSN:0931-041X
1432-198X
DOI:10.1007/s004670050234