Folic acid supplementation lowers blood arsenic

BACKGROUND: Chronic arsenic exposure currently affects >100 million persons worldwide. Methylation of ingested inorganic arsenic (InAs) to monomethylarsonic (MMAs) and dimethylarsinic (DMAs) acids relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic elimination. OBJECT...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2007-10, Vol.86 (4), p.1202-1209
Main Authors: Gamble, Mary V, Liu, Xinhua, Slavkovich, Vesna, Pilsner, J. Richard, Ilievski, Vesna, Factor-Litvak, Pam, Levy, Diane, Alam, Shafiul, Islam, Mominul, Parvez, Faruque, Ahsan, Habibul, Graziano, Joseph H
Format: Article
Language:English
Subjects:
adults
arsenic
Arsenic - blood
Arsenic - metabolism
Arsenic - urine
Arsenicals - metabolism
Arsenicals - urine
Bangladesh - epidemiology
Biological and medical sciences
blood chemistry
cacodylic acid
chronic toxicity
Dietary Supplements
Double-Blind Method
Environmental Exposure - adverse effects
Feeding. Feeding behavior
Female
folic acid
Folic Acid - administration & dosage
Folic Acid - blood
Folic Acid - pharmacology
Fundamental and applied biological sciences. Psychology
Homocysteine - blood
Humans
inorganic compounds
Male
Medicin och hälsovetenskap
methylation
Methylation - drug effects
Middle Aged
monomethylarsonic acid
nutrition assessment
nutritional intervention
nutritional status
randomized clinical trials
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B Complex - administration & dosage
Vitamin B Complex - blood
Vitamin B Complex - pharmacology
vitamin supplements
Water Pollutants, Chemical - blood
Water Pollutants, Chemical - metabolism
Water Pollutants, Chemical - urine
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Summary:BACKGROUND: Chronic arsenic exposure currently affects >100 million persons worldwide. Methylation of ingested inorganic arsenic (InAs) to monomethylarsonic (MMAs) and dimethylarsinic (DMAs) acids relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic elimination. OBJECTIVE: We hypothesized that folic acid supplementation to arsenic-exposed Bangladeshi adults would increase arsenic methylation and thereby lower total blood arsenic. DESIGN: In this randomized, double-blind, placebo-controlled trial, we evaluated blood concentrations of total arsenic, InAs, MMAs, and DMAs in 130 participants with low plasma folate (
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/86.4.1202