Acquired immune‐related and inflammatory conditions and subsequent chronic lymphocytic leukaemia

Summary Immune‐mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune‐related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals....

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Bibliographic Details
Published in:British journal of haematology 2007-12, Vol.139 (5), p.791-798
Main Authors: Landgren, Ola, Gridley, Gloria, Check, David, Caporaso, Neil E., Morris Brown, Linda
Format: Article
Language:English
Subjects:
Adult
aetiology
Anemia, Hemolytic, Autoimmune - complications
Anemia, Hemolytic, Autoimmune - epidemiology
Autoimmune Diseases - complications
Autoimmune Diseases - epidemiology
Biological and medical sciences
Chronic Disease
chronic lymphocytic leukaemia
Communicable Diseases - complications
Communicable Diseases - epidemiology
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
infectious disease
Inflammation - complications
Inflammation - epidemiology
Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology
Leukemia, Lymphocytic, Chronic, B-Cell - etiology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
pathogenesis
Pneumonia - complications
Pneumonia - epidemiology
Risk Factors
Sinusitis - complications
Sinusitis - epidemiology
susceptibility
United States - epidemiology
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Summary:Summary Immune‐mediated pathways have been recognized to be of importance in the pathogenesis of chronic lymphocytic leukaemia (CLL). We assessed a broad variety of immune‐related and inflammatory conditions and subsequent CLL development among 4 million adult male veterans admitted to VA hospitals. We identified 3,680 CLL cases with up to 27 years of follow‐up. Using Poisson regression analyses restricted to immune‐related or inflammatory conditions that occurred more than one year before CLL, we estimated relative risk (RR) and 95% confidence intervals for CLL risk. Elevated CLL risk was found among individuals with prior chronic sinusitis (RR = 1·27, 1·01–1·61). Pneumonia had a borderline (RR = 1·13, 1·00–1·27) association with CLL; the risk was further elevated (RR = 1·35, 1·07–1·72) for latency
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/j.1365-2141.2007.06859.x