Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects

The purpose of the present study was to investigate the possible relationship between a change in Thr 389 phosphorylation of p70S6 kinase (p70 S6k ) after a single resistance training session and an increase in skeletal muscle mass following short-term resistance training. Eight male subjects perfor...

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Bibliographic Details
Published in:European journal of applied physiology 2008-01, Vol.102 (2), p.145-152
Main Authors: Terzis, Gerasimos, Georgiadis, Giorgos, Stratakos, Grigoris, Vogiatzis, Ioannis, Kavouras, Stavros, Manta, Panagiota, Mascher, Henrik, Blomstrand, Eva
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Biopsy
Enzymes
Exercise
Exercise - physiology
Exercise Test
Fysiologi
Fysiologi och farmakologi
Health care
Human Physiology
Human subjects
Humans
Kinases
Male
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Muscle Contraction - physiology
Muscle, Skeletal - anatomy & histology
Muscle, Skeletal - physiology
Musculoskeletal system
Occupational Medicine/Industrial Medicine
Original Article
Phosphorylation
Physical education
Physical Exertion - physiology
Physiology
Physiology and pharmacology
Protein synthesis
Proteins
Ribosomal Protein S6 Kinases, 70-kDa - physiology
Signal transduction
Sports Medicine
Statistics as Topic
Strength training
Young Adult
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Summary:The purpose of the present study was to investigate the possible relationship between a change in Thr 389 phosphorylation of p70S6 kinase (p70 S6k ) after a single resistance training session and an increase in skeletal muscle mass following short-term resistance training. Eight male subjects performed an initial resistance training session in leg press, six sets of 6RM with 2 min between sets. Muscle biopsies were obtained from the vastus lateralis before (T1) and 30 min after the initial training session (T2). Six of these subjects completed a 14-week resistance-training programme, three times per week (nine exercises, six sets, 6RM). A third muscle biopsy was obtained at the end of the 14-week training period (T3). One repetition maximum (1RM) squat, bench press and leg press strength as well as fat-free mass (FFM, with dual energy X-ray absorptiometry) were determined at T1 and T3. The results show that the increase in Thr 389 phosphorylation of p70 S6k after the initial training session was closely correlated with the percentage increase in whole body FFM ( r  = 0.89, P  
ISSN:1439-6319
1439-6327
1439-6327
DOI:10.1007/s00421-007-0564-y