Variable Impact on Mortality of AIDS-Defining Events Diagnosed during Combination Antiretroviral Therapy: Not All AIDS-Defining Conditions Are Created Equal

Background. The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy. Methods. We analyzed data from 31,620 patients with no prior ADEs who started co...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-04, Vol.48 (8), p.1138-1151
Main Authors: Mocroft, Amanda, Sterne, Jonathan A C, Egger, Matthias, May, Margaret, Grabar, Sophie, Furrer, Hansjakob, Sabin, Caroline, Fatkenheuer, Gerd, Justice, Amy, Reiss, Peter, d'Arminio Monforte, Antonella, Gill, John, Hogg, Robert, Bonnet, Fabrice, Kitahata, Mari, Staszewski, Schlomo, Casabona, Jordi, Harris, Ross, Saag, Michael
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - diagnosis
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - mortality
Adult
AIDS
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - mortality
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretrovirals
Antiviral agents
Biological and medical sciences
Carts
Cohort Studies
Death
Disease transmission
Drug therapy
Drug Therapy, Combination
Epidemiology
Female
HIV
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Lymphoma, AIDS-Related - diagnosis
Lymphoma, AIDS-Related - mortality
Male
Medical sciences
Medicin och hälsovetenskap
Mortality
Mycobacterium avium
Pharmacology. Drug treatments
Physicians
Pneumocystis
Prognosis
Proportional Hazards Models
Pulmonary tuberculosis
Ribonucleic acid
RNA
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral load
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Summary:Background. The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy. Methods. We analyzed data from 31,620 patients with no prior ADEs who started combination antiretroviral therapy. Cox proportional hazards models were used to estimate mortality hazard ratios for each ADE that occurred in >50 patients, after stratification by cohort and adjustment for sex, HIV transmission group, number of antiretroviral drugs initiated, regimen, age, date of starting combination antiretroviral therapy, and CD4+ cell count and HIV RNA load at initiation of combination antiretroviral therapy. ADEs that occurred in
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1086/597468